A5027045540- Statistical Methods in Clinical Trials
- Musicology and Musical Analysis
- Prostate Cancer Diagnosis and Treatment
- Poetry Analysis and Criticism
- Prostate Cancer Treatment and Research
- Statistical Methods and Inference
- Health Systems, Economic Evaluations, Quality of Life
- Translation Studies and Practices
- Folklore, Mythology, and Literature Studies
- Narrative Theory and Analysis
- Gothic Literature and Media Analysis
- Medieval Literature and History
- German Literature and Culture Studies
- Alzheimer's disease research and treatments
- Literature: history, themes, analysis
- Russian Literature and Bakhtin Studies
- Digital Humanities and Scholarship
- American Constitutional Law and Politics
- Optimal Experimental Design Methods
- Renal cell carcinoma treatment
- Shakespeare, Adaptation, and Literary Criticism
- Dementia and Cognitive Impairment Research
- Art, Politics, and Modernism
- Language, Metaphor, and Cognition
- S100 Proteins and Annexins
University of Washington
2003-2024
Seattle Children's Hospital
2023-2024
Fred Hutch Cancer Center
2012-2020
Seattle University
2003-2019
Social Sciences and Humanities Research Council
2019
Shanghai Jiao Tong University
2019
University of Michigan
2015-2017
Harvard University
2017
Illinois Institute of Technology
2012-2016
Alzheimer’s Disease Neuroimaging Initiative
2015
The decision curve is a graphical summary recently proposed for assessing the potential clinical impact of risk prediction biomarkers or models recommending treatment intervention. It was applied in an article Journal Clinical Oncology to measure using genomic model deciding on adjuvant radiation therapy prostate cancer treated with radical prostatectomy. We illustrate use curves evaluating clinical- and biomarker-based predicting man’s cancer, which could be used guide biopsy. Decision are...
Other| September 01 1983 On Deconstruction: Theory and Criticism After Structuralism Jonathan Culler. Ithaca: Cornell University Press, 1982. 307 pp. $22.50. Marshall Brown Search for other works by this author on: This Site Google Modern Language Quarterly (1983) 44 (3): 327–330. https://doi.org/10.1215/00267929-44-3-327 Cite Icon Share Twitter Permissions Citation Brown; Structuralism. 1 1983; doi: Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote...
Other| June 01 1981 The Pursuit of Signs: Semiotics, Literature, Deconstruction CULLER JONATHAN. Ithaca: Cornell University Press, 1981. xiv + 242 pp. $15.00. Marshall Brown Search for other works by this author on: This Site Google Modern Language Quarterly (1981) 42 (2): 208–210. https://doi.org/10.1215/00267929-42-2-208 Cite Icon Share Twitter Permissions Citation Brown; Deconstruction. 1 1981; doi: Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote...
The 17-gene Oncotype DX Genomic Prostate Score (GPS) test predicts adverse pathology (AP) in patients with low-risk prostate cancer treated immediate surgery. We evaluated the GPS as a predictor of outcomes multicenter active surveillance cohort.Diagnostic biopsy tissue was obtained from men enrolled at 8 sites Canary Active Surveillance Study. primary endpoint AP (Gleason Grade Group [GG] ≥ 3, pT3a) who underwent radical prostatectomy (RP) after initial surveillance. Multivariable...
The many facets of the realism debate reflect complexity subject. Realism was an accepted standard value only during romantic period; it became more prominent later as problematic. Major senses “real” in nineteenth century are (1) universal essence, (2) irregular minute particular, and (3) causal regularity. Realist plotting typically juxtaposes background tableau foreground coup de theatre; realist style consists multiple silhouettings. is a semiosis by silhouetting. Hegel's analysis...
Abstract Despite the heightened interest in developing biomarkers predicting treatment response that are used to optimize patient decisions, there has been relatively little development of statistical methodology evaluate these markers. There is currently no unified framework for marker evaluation. This paper proposes a suite descriptive and inferential methods designed individual markers compare candidate An R software package developed which implements methods. Their utility illustrated...
Background: Alzheimer's disease (AD) is the most common type of dementia, with progressive onset clinical symptoms. The main pathological hallmarks are brain deposits extracellular amyloid beta plaques and intracellular neurofibrillary tangles (NFT). Cerebrospinal fluid reflects changes in brain; 1-42 a marker plaques, while total phosphorylated tau markers NFT formation. Additional biomarkers associated pathogenesis needed, for better prognosis, more specific diagnosis, prediction severity...
Recently, gene set analysis (GSA) has been extended from use on expression data to single-nucleotide polymorphism (SNP) in genome-wide association studies. When GSA demonstrated SNP data, two popular statistics (gene enrichment [GSEA] and Fisher's exact test [FET]) have used. However, GSEA FET shown a lack of power robustness the data. The purpose this work is investigate whether same issues are also true for Ultimately, we conclude that not optimal when compared with SUMSTAT method. In real...
Ovarian cancer is the most lethal gynecological malignancy. Our integrated -omics approach to ovarian biomarker discovery has identified kallikrein 6 (KLK6) and folate-receptor 1 (FOLR1) as promising candidates but these markers require further validation.KLK6, FOLR1, CA125, HE4 were investigated in three independent serum cohorts with a total of 20 healthy controls, 150 benign 216 patients. The levels determined by ELISA or automated immunoassay.All biomarkers demonstrated elevations sera...
Renal cell carcinoma (RCC) is frequently diagnosed incidentally as an early-stage small renal mass (SRM; pT1a, ≤4 cm). Overtreatment of patients with benign or clinically indolent SRMs increasingly common and has resulted in a recent shift treatment recommendations. There are currently no available biomarkers that can accurately predict clinical behavior. Therefore, we set out to identify early RCC progression. We employed quantitative label-free liquid chromatography coupled tandem...
Abstract Background Alzheimer’s disease (AD) is the most prevalent form of dementia. Currently, studied biomarkers AD are cerebrospinal fluid (CSF) amyloid β 1-42, total tau and phosphorylated tau. However, misdiagnosis can exceed 20%. Recently, we found that CSF precursor-like protein-1 (APLP1) neuronal pentraxin receptor (NPTXR) promising AD. The aim present study to validate APLP1 NPTXR as severity. Methods concentrations were measured in patients with mild cognitive impairment (MCI) (n =...
Decision curves are a tool for evaluating the population impact of using risk model deciding whether to undergo some intervention, which might be treatment help prevent an unwanted clinical event or invasive diagnostic testing such as biopsy. The common formulation decision is based on opt-in framework. That is, evaluated opt high-risk patients into in setting where standard care not treat. Opt-in display net benefit comparison reference policy treating no patients. In contexts, however,...