A5001550087- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Obesity and Health Practices
- Molecular Biology Techniques and Applications
- Obesity, Physical Activity, Diet
- Renal cell carcinoma treatment
- Organ Transplantation Techniques and Outcomes
- Systemic Sclerosis and Related Diseases
- Cancer Cells and Metastasis
- Transplantation: Methods and Outcomes
- Health Promotion and Cardiovascular Prevention
- Single-cell and spatial transcriptomics
- Skin Diseases and Diabetes
- Child and Adolescent Health
- Body Contouring and Surgery
- Liver Disease and Transplantation
King Saud bin Abdulaziz University for Health Sciences
2019-2024
King Abdullah International Medical Research Center
2024
Jewish General Hospital
2018-2020
McGill University
2018-2020
Centre Hospitalier de l’Université de Montréal
2018
Hôpital du Sacré-Cœur de Montréal
2018
John H. Stroger, Jr. Hospital of Cook County
2018
Abstract Response to neoadjuvant chemotherapy (NAC) in triple negative breast cancer (TNBC) is highly prognostic and determines whether adjuvant needed if residual tumor found at surgery. To evaluate the predictive values of circulating DNA (ctDNA) this setting, we analyzed serial bloods from 26 TNBC patients collected prior, during, after NAC. Individual digital droplet PCR assays were developed for 121 variants (average 5/patient) identified sequencing, enabling ctDNA detection 96%...
Abstract Background: Circulating free DNA (cfDNA) is an exciting novel method to diagnose, monitor, and predict resistance response cancer therapies, with the potential radically alter management of patients. To fulfill its potential, greater knowledge about preanalytical variables required optimize standardize collection process, maximize yield utility small quantities cfDNA extracted. Methods: this end, we have compared extraction efficiency three different protocols, including a protocol...
BMI is a feasible and recommended measure for overweight obesity screening in children adolescents. The study aimed to determine how often physicians correctly identified obesity/ status adolescents by using percentile charts.This retrospective cross-sectional reviewed the paper medical records of (6-14 years) who visited family medicine pediatric outpatient clinics (Jan-June 2012) city Riyadh. Investigators calculated percentiles (using height, weight, age gender data retrieved from...
594 Background: TNBC, the most aggressive form of breast cancer, is treated primarily with chemotherapy, even before surgery (neoadjuvant chemotherapy or NAC). The prognosis and need for adjuvant therapy depends greatly on tumor response assessed by pathology (pCR). Highly sensitive specific ctDNA assays have been shown to be prognostic value in metastatic settingbut not yet earlier settings. Methods: Tissue was collected from 26 Q-CROC-03 clinical trial TNBC patients before, during after...
Abstract Background: Liquid biopsies to monitor response treatment are a minimally invasive and highly attractive method for clinical application. Detection of ctDNA in plasma is now sensitive thanks the use novel specific techniques such as ddPCR. In present study we set out analyze utility using patients receiving standard neoadjuvant chemotherapy triple negative breast cancer. Methods: Serial blood was collected from cancer participating Q-CROC-03 trial (NCT01276899). The recruited...