A5025450036- Nicotinic Acetylcholine Receptors Study
- Connexins and lens biology
- Yersinia bacterium, plague, ectoparasites research
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Axon Guidance and Neuronal Signaling
- Biochemical effects in animals
Fundación Ciencia and Vida
2021-2024
San Sebastián University
2021-2024
Universidad Andrés Bello
2019
Abstract In the adult hippocampus, new neurons are generated in dentate gyrus. The Wnt signaling pathway regulates this process, but little is known about endogenous ligands involved. We investigated role of Wnt5a on hippocampal neurogenesis. neuronal morphogenesis during embryonic development, and maintains dendritic architecture pyramidal hippocampus. Here, we determined that knockdown mouse gyrus by lentivirus-mediated shRNA impaired differentiation progenitor cells, reduced development...
Abstract Background Members of the β-subfamily connexins contain an intracellular pocket surrounded by amino acid residues from four transmembrane helices. The presence this has not previously been investigated in members α-, γ-, δ-, and ε-subfamilies. We studied connexin50 (Cx50) as a representative α-subfamily, because its structure determined mutations Cx50 are among most common genetic causes congenital cataracts. Methods To investigate function we used molecular dynamics simulation,...
Connexin hemichannels allow the unspecific but regulated interchange of molecules from ions to second messenger and ATP, between eukariotic cell its extracellular space. The transport water through is important for physiological functions also in progression several pathological conditions. Extracellular Ca2+ concentration one regulators that drives channel a closed state. However relation their functional structural states far being totally understood. In this work, we modelled connexin...