A5083591521- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Minimally Invasive Surgical Techniques
- AI in cancer detection
- Mast cells and histamine
- Adsorption and Cooling Systems
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Robot Manipulation and Learning
- Kruppel-like factors research
- Advanced Vision and Imaging
- Advanced Sensor and Control Systems
- Olfactory and Sensory Function Studies
- Advanced Computational Techniques and Applications
- Wnt/β-catenin signaling in development and cancer
- DNA Repair Mechanisms
- Sleep and Wakefulness Research
- Robotics and Sensor-Based Localization
Zhuzhou Central Hospital
2020-2025
Central South University
2020-2025
Beijing Academy of Artificial Intelligence
2022
Peking University
2022
Fudan University
2019
State Key Laboratory of Medical Neurobiology
2019
Shanghai Jiao Tong University
2012
Abstract Background and Aims Distinguishing pancreatic cancer from nonneoplastic masses is critical remains a clinical challenge. The study aims to construct deep learning‐based artificial intelligence system facilitate mass diagnosis, guide EUS‐guided fine‐needle aspiration (EUS‐FNA) in real time. Methods This prospective study. CH‐EUS MASTER composed of Model 1 (real‐time capture segmentation) 2 (benign malignant identification). It was developed using convolutional neural networks Random...
Background: Both hypoxia and long non-coding RNAs (lncRNAs) contribute to the tumor progression in hepatocellular carcinoma (HCC). We sought establish a hypoxia-related lncRNA signature explore its correlation with immunotherapy response HCC. Materials Methods: Hypoxia-related differentially expressed lncRNAs (HRDELs) were identified by conducting differential gene expression analyses GSE155505 The Cancer Genome Atlas (TCGA)- liver (LIHC) datasets. HRDELs landscape patients HCC TCGA-LIHC was...
Colorectal cancer (CRC) is one of the most common malignancies and causes cancer-related mortality worldwide. Cell proliferation tumor metastasis as well chemoresistance are correlated with poor survival CRC. The interferon regulatory factor 6 (IRF6) functioned a suppressor gene in several cancers associated risk We explored role IRF6 CRC present study. protein expressions human tissues, normal para-carcinoma tissue liver metastases from were measured. proliferation, chemotherapeutic...
Circular RNA (circRNA) has attracted extensive attention in studies related to the malignant progression of cancer, including hepatocellular carcinoma (HCC). Therefore, its molecular mechanism HCC needs be further explored.The expression levels circ_0008285, microRNA (miR)-384 and ribonucleotide reductase subunit M2 (RRM2) mRNA were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation was analyzed using cell counting kit-8 assay 5-ethynyl-2'-deoxyuridine...
GRHL3 is a factor associated with tumor, of which the molecular mechanism remains further investigation. We explored underlying tumor-promoting effect in colorectal cancer (CRC), involved MEK1/2 pathway. The expression was measured CRC and adjacent normal tissue using qPCR immunohistochemical staining. Lentivirus-mediated knockdown performed cell line HT29. Cell proliferation metastasis were assayed vitro, tumorigenicity investigated vivo. found higher cancer, negatively correlated patients’...
Background. Acidosis in the tumor microenvironment (TME) is involved immune dysfunction and progression. We attempted to develop an acidosis-related index (ARI) signature improve prognostic prediction of pancreatic carcinoma (PC). Methods. Differential gene expression analyses two public datasets (GSE152345 GSE62452) from Gene Expression Omnibus database were performed identify genes. The Cancer Genome Atlas–pancreatic (TCGA-PAAD) cohort TCGA was set as discovery dataset. Univariate Cox...
The present study aimed to identify hub genes associated with the treatment and control of active inactive Crohn's disease (CD).
Object pose estimation refers to the of objects' position and orientation relative camera coordinate system using visual information. It is fundamental grasp point selection motion planning in robot grasping. Different from other works depth vision sensors, this work discusses approach estimating specially with unilateral unordered clouds single objects In paper, we propose directly consume estimate 3D orientations predefined canonical posture, which utilizes PointCNN [1]. A dataset also...
Abstract BACKGROUND: Gastric cancer (GC) is an aggressive malignancy, and patients with advanced-stage GC have high rates of morbidity. The long intergenic non-protein coding RNA 1224 (LINC01224) functions in the pathogenesis many cancers. We performed vitro vivo studies to investigate effects mechanism LINC01224 this cancer. METHODS: qRT-PCR was used measure expression LINC01224, western blotting were genes PI3K/AKT/mTOR/HIF-1α axis (phosphoinositide 3-kinase [PI3K], AKT, mammalian target...
Roof plate specific spondins (Rspos) are important activators of the Wnt signaling pathway discovered recently. Rspos include four secreted proteins: Rspo1, Rspo2, Rspo3, and Rspo4.They mainly involved in regulation cell proliferation differentiation via regulating canonical Wnt/β-catenin pathway.The physiological functions sex selection, limb development, organ formation development. pathogenesis some malignant tumors, roles vary different types tumors.特异性顶部盘状底板反应蛋白(roof...