A5079657644- Nicotinic Acetylcholine Receptors Study
- ATP Synthase and ATPases Research
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Protein Structure and Dynamics
- bioluminescence and chemiluminescence research
- Bacterial Genetics and Biotechnology
- Marine Toxins and Detection Methods
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- RNA and protein synthesis mechanisms
- Electrochemical Analysis and Applications
- Lipid Membrane Structure and Behavior
- Cardiomyopathy and Myosin Studies
Science for Life Laboratory
2025
Stockholm University
2022-2025
Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions membrane. Here, we elucidate intricate role of cardiolipin (CDL), a regulatory lipid, as stabilizer complexes. Using silico -designed model protein TMHC4_R (ROCKET) scaffold, employ combination molecular dynamics simulations native mass spectrometry to explore features that facilitate preferential lipid mediate stabilization. We find spatial...
Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions membrane. Here, we elucidate intricate role of cardiolipin (CDL), a regulatory lipid, as stabilizer complexes. Using silico -designed model protein TMHC4_R (ROCKET) scaffold, employ combination molecular dynamics simulations native mass spectrometry to explore features that facilitate preferential lipid mediate stabilization. We find spatial...
Ligand-gated ion channels are critical mediators of electrochemical signal transduction across evolution. The bacterial channel DeCLIC constitutes a provocative model system for structure, function, and dynamics in this family, including modulatory N-terminal domain (NTD). Previous closed structures support rationale its inhibition by calcium; however, properties open state remain unclear. Here we used cryogenic electron microscopy under acidic conditions to determine previously unreported...
Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) are critical for the action neurotransmitters and many psychoactive drugs. However, details their modulatory mechanisms remain unclear, especially beyond orthosteric neurotransmitter-binding sites. The recently reported prokaryotic symbiont Tevnia jerichonana channel (sTeLIC), a pH-gated homologue eukaryotic receptors in pLGIC family, is thought to be modulated by aromatic compounds via relatively uncharacterised site...
Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions membrane. Here, we elucidate intricate role of cardiolipin (CDL), a regulatory lipid, as stabilizer complexes. Using silico -designed model protein TMHC4_R (ROCKET) scaffold, employ combination molecular dynamics simulations native mass spectrometry to explore features that facilitate preferential lipid mediate stabilization. We find spatial...
Abstract Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) is critical to the action neurotransmitters and many psychoactive drugs. However, details their modulatory mechanisms remain unclear, especially beyond orthosteric neurotransmitter-binding sites. The recently reported prokaryotic channel sTeLIC, a pH-gated homolog eukaryotic receptors in pLGIC family, thought be modulated by aromatic compounds via relatively uncharacterized site extracellular vestibule. Here, we...
Abstract Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions membrane. Here, we elucidate intricate role of cardiolipin (CDL), a regulatory lipid, as stabilizer complexes. Using silico -designed model protein TMHC4_R (ROCKET) scaffold, employ combination molecular dynamics simulations native mass spectrometry to explore features that facilitate preferential lipid mediate stabilization. We find...