A5086394565- Gastrointestinal motility and disorders
- Chemical synthesis and alkaloids
- Glioma Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Macrophage Migration Inhibitory Factor
- Neuroinflammation and Neurodegeneration Mechanisms
- Fungal Biology and Applications
- Phytochemical Studies and Bioactivities
- Magnolia and Illicium research
- Chronic Myeloid Leukemia Treatments
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Acute Myeloid Leukemia Research
- Nuclear Receptors and Signaling
- Chronic Lymphocytic Leukemia Research
- Plant chemical constituents analysis
- Advanced Glycation End Products research
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
Korea Institute of Oriental Medicine
2020-2024
Convergence Research Center for Diagnosis Treatment and Care System of Dementia
2020
Korea Institute of Science and Technology
2020
Chungnam National University
2015-2017
// Yunseon Jang 1 , Jeongsu Han Soo Jeong Kim Jungim Min Joung Lee Soyeon Ryu 1, 2 Kang-Sik Seo 3 Song-Yi Choi 4 Minho Shong 5 Kyu Lim Jun Young Heo 6 Gi Ryang Kweon Department of Biochemistry, Chungnam National University School Medicine, Daejeon, Republic Korea, 301-747 Research Institute for Medical Science, R&D center, KT&G Life Sciences Pathology, Internal Brain research institute, Correspondence to: Kweon, e-mail: mitochondria@cnu.ac.kr Heo, junyoung3@gmail.com Keywords: auraptene,...
Among the primary brain tumors, glioblastoma multiforme (GBM) has a radical proliferation ability that complicates therapeutic modulation of cancer progression. The majority GBM patients have low survival rate (<1 year) due to tumor growth and late diagnosis. Previous reports shown astrocytes specific metabolic organization includes production lactate, storage glycogen, use lactate support neurons which possess higher capacity metabolism compared neurons. We hypothesized these...
Mumefural is a bioactive compound derived from the processed fruit of Prunus mume Sieb. et Zucc., traditional health food; however, its safety has not been evaluated. We investigated toxicity mumefural through single and repeated oral administration at doses 1250, 2500, 5000 mg/kg in Institute Cancer Research (ICR) mice. The acute assessment was associated with adverse effects or death. Similarly, subacute (four weeks) did reveal any mumefural-associated mortality, abnormal organ damage,...
Most studies on the pathogenesis of inflammatory bowel disease (IBD) focus gut function damage and gastrointestinal symptoms; however, psychiatric disorders, including depression anxiety, have also been recognized as significant causes. Recently, we reported that Magnolia officinalis bark extract (MBE) alleviated enterocyte death in dextran sulfate sodium (DSS)-induced colitis mouse model mimics IBD; therapeutic effects MBE neurological symptoms underlying mechanisms IBD remain unclear. In...
Long-term imatinib treatment induces drug-resistant chronic myeloid leukemia (CML) cells harboring T315I gate keeper mutation of breakpoint cluster region (BCR)-ABL oncogenic kinase. However, although cell proliferation is coupled with cellular energy status in CML carcinogenesis, the metabolic characteristics T315I-mutant have never been investigated. Here, we analyzed activities and phenotypes, including proliferation, oxygen consumption, lactate production, redox state KBM5...
Objectives Based on a report that Prunus mume fruits affect gut function and microflora, we hypothesized mumefural (MF), one of the active compounds processed fruits, could intestinal or microbiome. Methods investigated effects orally administered MF environment by analyzing changes in fecal, intestinal, microbiome murine model. Results No body weight fecal parameters C57BL/6 mice were observed following administration. However, quantity residual feces large small intestines cecum was...
Purpose : The purpose of this study is to investigate the effect veral abuse and emotional labor on psychological well-being call center workers in COVID-19 environment. Methods data collection was conducted from March 10 April 15, 2022, analysis performed using t-test, ANOVA, correlation multiple regression SPSS/WIN 23.0. Results factors affecting subjects were found be family living together(t=5.23, p<.001) monthly average income(t=4.74, general work-related characteristics. It that verbal...