A5102736047- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Barrier Structure and Function Studies
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Nuclear Receptors and Signaling
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Intensive Care Unit Cognitive Disorders
- Ferroptosis and cancer prognosis
- Regulation of Appetite and Obesity
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Electron Spin Resonance Studies
- Thyroid Cancer Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Paraquat toxicity studies and treatments
- Lipid metabolism and disorders
- Ginseng Biological Effects and Applications
- Inflammasome and immune disorders
- Genetic and Kidney Cyst Diseases
Chungnam National University
2015-2024
// Yunseon Jang 1 , Jeongsu Han Soo Jeong Kim Jungim Min Joung Lee Soyeon Ryu 1, 2 Kang-Sik Seo 3 Song-Yi Choi 4 Minho Shong 5 Kyu Lim Jun Young Heo 6 Gi Ryang Kweon Department of Biochemistry, Chungnam National University School Medicine, Daejeon, Republic Korea, 301-747 Research Institute for Medical Science, R&D center, KT&G Life Sciences Pathology, Internal Brain research institute, Correspondence to: Kweon, e-mail: mitochondria@cnu.ac.kr Heo, junyoung3@gmail.com Keywords: auraptene,...
The highly dynamic changes in microglia necessary to achieve a rapid neuroinflammatory response require supply of energy from mitochondrial respiration, which leads the accumulation unfolded proteins. We previously reported that microglial activation is correlated with protein (UPRmt) kaolin-induced hydrocephalus model, but we still do not know extent these are involved cytokine release. Here, investigated BV-2 cells and found treatment lipopolysaccharide (LPS) for 48 h increased secretion...
Among the primary brain tumors, glioblastoma multiforme (GBM) has a radical proliferation ability that complicates therapeutic modulation of cancer progression. The majority GBM patients have low survival rate (<1 year) due to tumor growth and late diagnosis. Previous reports shown astrocytes specific metabolic organization includes production lactate, storage glycogen, use lactate support neurons which possess higher capacity metabolism compared neurons. We hypothesized these...
Cerebral endothelial cells (ECs) require junctional proteins to maintain blood–brain barrier (BBB) integrity, restricting toxic substances and controlling peripheral immune with a higher concentration of mitochondria than ECs capillaries. The mechanism underlying BBB disruption by defective mitochondrial oxidative phosphorylation (OxPhos) is unclear in mitochondria-related gene-targeted animal model. To assess the role EC OxPhos function maintenance BBB, we developed an EC-specific...
Abstract The Arg/N-degron pathway, which is involved in the degradation of proteins bearing an N-terminal signal peptide, connected to p62/SQSTM1-mediated autophagy. However, impact molecular link between N-degron and autophagy pathways largely unknown context systemic inflammation. Here, we show that chemical mimetics Nt-Arg pathway (p62 ligands) decreased mortality sepsis inhibited pathological inflammation by activating mitophagy immunometabolic remodeling. p62 ligands alleviated a mouse...
(1) Background: Nonthermal plasma (NTP) induces cell death in various types of cancer cells, providing a promising alternative treatment strategy. Although recent studies have identified new mechanisms NTP several cancers, the molecular underlying its therapeutic effect on thyroid (THCA) not been elucidated. (2) Methods: To investigate mechanism NTP-induced death, THCA lines were treated with NTP-activated medium -(NTPAM), and gene expression profiles evaluated using RNA sequencing. (3)...
Abstract Mitochondrial function and innate immunity are intimately linked; however, the mechanisms how mitochondrion-shaping proteins regulate host defense remains largely unknown. Herein we show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes through maintenance of aerobic glycolysis xenophagy via hypoxia-inducible factor (HIF)-1α during intracellular bacterial infection. Myeloid-specific MFN2 deficiency in mice impaired antimicrobial inflammatory responses against...
Endothelial cells (ECs) in cerebral vessels are considered the primary targets acute hemorrhagic brain injuries. EC dysfunction can aggravate neuronal injuries by causing secondary inflammatory responses and blood-brain barrier (BBB) disruption. Previous studies have reported that enhancement of mitochondrial function within ECs may reduce BBB disruption decrease severity However, molecular signaling pathways through which enhanced is to exert this protective effect not been fully...
Yunseon Jang, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Ilhwan Ryu,Xianshu Ju, Ryu, Woosuk Chung, Eungseok Oh, Gi Ryang Kweonand Jun Young Heo. Exp Neurobiol 2017;26:104-12. https://doi.org/10.5607/en.2017.26.2.104
Current therapeutics for Parkinson's disease (PD) are only effective in providing relief of symptoms such as rigidity, tremors and bradykinesia, do not exert disease-modifying effects by directly modulating mitochondrial function. Here, we investigated auraptene (AUR) a potent therapeutic reagent that specifically protects neurotoxin-induced reduction respiration inhibits reactive oxygen species (ROS) generation. Further, explored the mechanism potency AUR protecting dopaminergic neurons....
The global incidence of Mycobacterium abscessus (Mabc), a rapidly growing nontuberculous mycobacterial strain that causes treatment-refractory pulmonary diseases, is increasing. Despite this, the host factors allow for protection against infection are largely unknown. In this study, we found sirtuin 3 (SIRT3), mitochondrial protein deacetylase, plays critical role in defense Mabc infection. decreased SIRT3 and upregulated oxidative stress macrophages. deficiency led to increased bacterial...
Junctional proteins in cerebrovascular endothelial cells are essential for maintaining the barrier function of blood-brain (BBB), thus protecting brain from infiltration pathogens. The present study showed that potential therapeutic natural compound auraptene (AUR) enhances junction assembly by inducing antioxidant enzymes and mitochondrial unfolded protein response (mtUPR). Treatment mouse with AUR enhanced expression junctional proteins, such as occludin, zonula occludens-1 (ZO-1) vascular...
Long-term imatinib treatment induces drug-resistant chronic myeloid leukemia (CML) cells harboring T315I gate keeper mutation of breakpoint cluster region (BCR)-ABL oncogenic kinase. However, although cell proliferation is coupled with cellular energy status in CML carcinogenesis, the metabolic characteristics T315I-mutant have never been investigated. Here, we analyzed activities and phenotypes, including proliferation, oxygen consumption, lactate production, redox state KBM5...
Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer’s disease (AD) dementia. Intracellular energy produced via mitochondrial respiration used the regulation of synaptic plasticity structure, dendritic spine length density, as well for release neurotrophic factors involved learning memory. To date, a few synthetic agents improving function have been developed overcoming cognitive impairment. However, no natural compounds that modulate by directly...
Paraquat (PQ), an herbicide considered environmental contributor to the development of Parkinson's disease (PD), induces dopaminergic neuronal loss through reactive oxygen species (ROS) production and oxidative stress by mitochondrial complex I. Most patients with PQ-induced PD are affected chronic exposure require a preventive strategy for modulation progression. To identify drugs that effective in preventing PD, we screened more than 1000 currently used clinics studies employing PQ-treated...
Ventriculomegaly induced by the abnormal accumulation of cerebrospinal fluid (CSF) leads to hydrocephalus, which is accompanied neuroinflammation and mitochondrial oxidative stress. The stress activates unfolded protein response (UPRmt), essential for homeostasis. However, association inflammatory UPRmt in pathogenesis hydrocephalus still unclear. To assess their relevance we established a kaolin-induced model 8-week-old male C57BL/6J mice evaluated it over time. We found that...
Mitochondrial targeted therapy is a next‐generation therapeutic approach for cancer that refractory to conventional treatments. damage caused by the excessive accumulation of reactive oxygen species (ROS) principle mitochondrial therapy. ROS in nonthermal plasma‐activated media (NTPAM) are known mediate anticancer effects various cancers including head and neck (HNC). However, signaling mechanism HNC cell death via NTPAM‐induced has not been fully elucidated. This study evaluated NTPAM...
Abstract Early exposures to anesthetics can cause long-lasting changes in excitatory/inhibitory synaptic transmission (E/I imbalance), an important mechanism for neurodevelopmental disorders. Since E/I imbalance is also involved with addiction, we further investigated possible addiction-related behaviors after multiple ketamine anesthesia late postnatal mice. Postnatal day (PND) 16 mice received (35 mg kg −1 , 5 days), and behavioral were evaluated at PND28 PND56. Although exposed early...