A5053510776- RNA Research and Splicing
- RNA modifications and cancer
- Parkinson's Disease Mechanisms and Treatments
- Advanced biosensing and bioanalysis techniques
- Nuclear Receptors and Signaling
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Connexins and lens biology
- Customer Service Quality and Loyalty
- Oral and Maxillofacial Pathology
- Ion Channels and Receptors
- Protein Kinase Regulation and GTPase Signaling
- Mechanical and Optical Resonators
- Amyotrophic Lateral Sclerosis Research
- Biosensors and Analytical Detection
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Hydrogen's biological and therapeutic effects
- Hedgehog Signaling Pathway Studies
- Autophagy in Disease and Therapy
- Veterinary Oncology Research
Yonsei University
2021
Hanyang University
2014-2019
Hanyang University Medical Center
2019
Bio-Medical Science (South Korea)
2017
Anyang University
2015
Abstract The stability and quality of metazoan mRNAs are under microRNA (miRNA)-mediated nonsense-mediated control. Although UPF1, a core mediator mRNA decay (NMD), mediates the target in 3′UTR-length-dependent manner, detailed mechanism remains unclear. Here, we suggest that is not mediated by nonsense but rather miRNAs downregulate via Ago-associated UPF1/SMG7. Global analyses response to UPF1 RNA interference miRNA-deficient cells reveal requires canonical miRNA targeting. destabilization...
MicroRNAs (miRNAs) are important regulators of gene translation and have been suggested as potent biomarkers in various disease states. In this study, we established an efficient method for simultaneous determination multiple miRNA levels, employing the previously developed SPC-SBE (solid phase capture-single base extension) approach MALDI-TOF mass spectrometry (MS). approach, first perform reverse transcription miRNAs extracted using stem-loop primers. Then cDNA is co-amplified with...
A 13-year-old neutered male Poodle dog was presented with a third eyelid mass in the left eye.The had undergone local resection of about year prior private practice.On cytological examination, diagnosed as adenocarcinoma.Although lung and lymph node metastases were suspected, based upon computed tomographic results, exenteration performed to relieve chronic pain improve dog's quality life.Exenteration carried good prognosis no tumor recurrence until 1 10 months after surgery, when occurred...