Psychological ownership over virtual and physical spaces in augmented reality can lead to tensions between collaborators, yet, there is still a significant challenge understanding how psychological manifests shared AR what that might mean for the inclusion of collaborative interaction mechanisms. Through an experimental instruction task with teleAR system, we interviewed 16 participant pairs on their perceptions they thought impacted within those spaces. Our findings indicate (1) introduces...

Abstract MicroRNA (miRNA) processing is a critical step in mature miRNA production. Its dysregulation leads to an increase isoforms with heterogenous 5′-ends (isomiRs), which can recognize distinct target sites because of their shifted seed sequence. Although some genes display productive expression 5′-isomiRs cancers, how production controlled and affect tumor progression have yet be explored. In this study, based on integrative analyses high-throughput sequencing data produced by our group...

Abstract The stability and quality of metazoan mRNAs are under microRNA (miRNA)-mediated nonsense-mediated control. Although UPF1, a core mediator mRNA decay (NMD), mediates the target in 3′UTR-length-dependent manner, detailed mechanism remains unclear. Here, we suggest that is not mediated by nonsense but rather miRNAs downregulate via Ago-associated UPF1/SMG7. Global analyses response to UPF1 RNA interference miRNA-deficient cells reveal requires canonical miRNA targeting. destabilization...

Augmented Reality (AR) systems have been proposed as solutions to reinforce remote collaboration over performing physical tasks by integrating digital information into the environment. However, there is a fundamental gap that arises from difference in degree which and local workers interact with virtual objects, attributed differing senses of ownership these objects. Addressing this gap, my thesis investigates how collaborative functionality affects psychological shared AR workspaces....

The introduction of Augmented Reality (AR) Head Mounted Displays (HMDs) in collaboration between remote and local workers, introduces new challenges given that camera views are now mobile. We introduce HoloMentor, an AR HMD-based collaborative system designed for instruction over live mobile during physical tasks. Through Actionport, we provide a world-stabilized area where helpers can dynamically place pointer annotations on the environment. Actionpad, indirect input mechanism with absolute...

All metazoan mRNAs have a poly(A) tail at the 3′ end with exception of replication-dependent histone (RDH) mRNAs, which in highly conserved stem-loop (SL) structure. However, subset RDH are reported to be polyadenylated under physiologic conditions. The molecular details biogenesis [poly(A)+ RDH] remain unknown. In this study, our genome-wide analyses reveal that puromycin treatment or UVC irradiation stabilizes poly(A)+ relative canonical an SL We demonstrate stabilization occurs...

In the following position paper we introduce use of AR HMD for remote instruction in healthcare and present challenges our team has faced achieving this application two contexts: surgical telementoring paramedic teleconsulting. After presentation how these come to be indications on address them, argue that those who wish pursue area research must grounded best practices from field CSCW integrated with technical innovations interaction development. This is a truly interdisciplinary...

Improper miRNA biogenesis produces the 5' variants of with a shifted seed region (also called isomiRs). Although presence stably abundant isomiRs were repeatedly reported, it is still unclear whether generation results either from mistake microprocessor or regulation by other intrinsic extrinsic factors, and participate in critical cellular processes, particularly cancer progress. Here, we performed both high-throughput RNA sequencing (RNA-seq) small (sRNA-seq) 75 hepatocellular carcinoma...

Abstract Improper miRNA biogenesis produces the 5’ variants of with a shifted seed region (also called isomiRs). Although presence stably abundant isomiRs were repeatedly reported, it is still unclear whether generation results either from mistake microprocessor or regulation by other intrinsic extrinsic factors, and participate in critical cellular processes, particularly cancer progress. Here, we performed both high-throughput RNA sequencing (RNA-seq) small (sRNA-seq) 75 hepatocellular...