A5103162253- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
Third Affiliated Hospital of Sun Yat-sen University
2024-2025
Sun Yat-sen University
2024-2025
Shenzhen University
2023
Background It is unknown whether the additional information provided by multiparametric dual-energy CT (DECT) could improve noninvasive diagnosis of aggressive macrotrabecular-massive (MTM) subtype hepatocellular carcinoma (HCC). Purpose To evaluate diagnostic performance dual-phase contrast-enhanced DECT for predicting MTM HCC. Materials and Methods Patients with histopathologic examination-confirmed HCC who underwent between June 2019 2022 were retrospectively recruited from three...
High drug resistance remains a challenge for chemotherapy against hepatocellular carcinoma (HCC). Combining chemotherapeutic agents with microRNA (miRNA), which simultaneously regulates multiple pathways, offers promising approach to improve therapeutic efficacy HCC. Although cationic amphiphilic copolymers have been used co-deliver these agents, their effectiveness is often limited by low co-encapsulation efficiency and inherent toxicity. In this study, we developed facile doxorubicin (DOX)...
Background Hepatocellular carcinoma (HCC) heterogeneity impacts prognosis, and imaging is a potential indicator. Purpose To characterize HCC image subtypes in MRI correlate with recurrence. Study Type Retrospective. Population A total of 440 patients (training cohort = 213, internal test 140, external 87) from three centers. Field Strength/Sequence 1.5‐T /3. 0‐T , fast/turbo spin‐echo T 2 ‐weighted, echo‐planar diffusion‐weighted, contrast‐enhanced three‐dimensional gradient‐recalled‐echo 1...
A histologic sign known as “vessels encapsulating tumor clusters” (VETC) has been shown to be a powerful predictor of aggressive hepatocellular carcinoma (HCC) and is associated with unfavorable prognosis. It previously demonstrated that MR elastography (MRE)-based stiffness shear strain mapping are promising in prediction HCC aggressiveness. We investigated the diagnostic performance MRE for predicting VETC finding HCC. Our results showed 3D MRE-based peritumor OSS-pLSL performed well...
Motivation: Hepatocellular carcinoma (HCC) exhibits significant intertumoral heterogeneity, which contributes significantly to treatment resistance and failure. Noninvasive imaging radiomics for preoperative decoding of the subtypes prognosis may be valuable in clinical management. Goal(s): To preoperatively develop validate clustering analysis HCC based on MRI features identifying with discrete prognosis. Approach: We performed detect distinct subtypes, subsequently clinicopathological...
Motivation: The MRI LI-RADS v2018 table is complex and has insufficient sensitivity. Goal(s): To evaluate the diagnostic performance of simplified for HCC on ECA-MRI, to determine value AFP level as an additional major feature. Approach: We developed compared per-lesion sensitivity defined by v2018, table, both them combined with ≥ 200 ng/mL. Results: Compared LR-5 provided higher comparable specificity HCC. ng/mL may be a suitable feature further improving sLR-5 classification....