A5006007970- Iron Metabolism and Disorders
- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- Insect and Pesticide Research
- Studies on Chitinases and Chitosanases
- Biomarkers in Disease Mechanisms
- Alcohol Consumption and Health Effects
- Glutathione Transferases and Polymorphisms
- Insect Utilization and Effects
- Plant Micronutrient Interactions and Effects
- Immune Cell Function and Interaction
- Genetic Mapping and Diversity in Plants and Animals
- Genomics, phytochemicals, and oxidative stress
- Diet, Metabolism, and Disease
- Pregnancy and preeclampsia studies
- Plant Stress Responses and Tolerance
- Glycosylation and Glycoproteins Research
- Cannabis and Cannabinoid Research
- Plant Pathogenic Bacteria Studies
- Gene expression and cancer classification
- Neurobiology and Insect Physiology Research
- Erythropoietin and Anemia Treatment
- Plant-Microbe Interactions and Immunity
- Trace Elements in Health
- Liver Disease Diagnosis and Treatment
Korea Research Institute of Bioscience and Biotechnology
2024
Chonnam National University
2020-2022
Red flour beetle, Tribolium castaneum (T. castaneum), is a major agricultural pest that causes significant damage to stored grains and products. Although hormone receptor 96 (HR96) known be the single ortholog corresponding mammalian constitutive androstane pregnane X receptor, structural features of HR96 (TcHR96) its role in insecticide-mediated transcription control cytochrome P450 enzyme genes T. have not been elucidated yet.We cloned full-length complementary DNA encoding TcHR96 revealed...
The pineal hormone, melatonin, plays important roles in circadian rhythms and energy metabolism. hepatic peptide hepcidin, regulates iron homeostasis by triggering the degradation of ferroportin (FPN), protein that transfers cellular to blood. However, role melatonin transcriptional regulation hepcidin is largely unknown. Here, we showed upregulates gene expression enhancing receptor 1 (MT1)-mediated c-Jun N-terminal kinase (JNK) activation hepatocytes. Interestingly, was increased during...
Hepatic peptide hormone hepcidin, a key regulator of iron metabolism, is induced by inflammatory cytokine interleukin-6 (IL-6) in the pathogenesis anemia inflammation or microbial infections. Small heterodimer partner-interacting leucine zipper protein (SMILE)/CREBZF transcriptional corepressor nuclear receptors that control hepatic glucose and lipid metabolism. Here, we examined role SMILE regulating metabolism signals. Overexpression significantly decreased activation Janus kinase 2-signal...
Chitin, a major component of insect cuticles, plays critical role in molting and morphogenesis. Thus, coordination chitin remodeling during development requires tight transcriptional control the metabolism genes involved synthesis, assembly degradation. However, molecular mechanism underlying beetle is not yet completely understood.We cloned full-length cDNA encoding hormone receptor 3 (TcHR3) from Tribolium castaneum showed TcHR3 modulating gene expression molting. Genome-wide transcriptome...
Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling response to changes the status. Small heterodimer partner-interacting leucine zipper (SMILE), polyphenol-inducible transcriptional co-repressor, regulates hepatic gluconeogenesis and lipogenesis. Here, we examine epigallocatechin-3-gallate (EGCG) effect on BMP-6-mediated SMAD1/5/8 transactivation hepcidin gene. EGCG treatment significantly...
Orphan nuclear receptor estrogen-related γ (ERRγ) is an important transcription factor modulating gene involved in endocrine control of liver metabolism. Transferrin 2 (TFR2), a carrier protein for transferrin, hepatic iron overload alcoholic disease (ALD). However, TFR2 transcriptional regulation hepatocytes remains largely unknown. In this study, we described detailed molecular mechanism expression involving ERRγ response to endocannabinoid 2-arachidonoylglycerol (2-AG). Treatment with...