A5015476729- Gastrointestinal motility and disorders
- Child Nutrition and Feeding Issues
- Infant Health and Development
- Congenital gastrointestinal and neural anomalies
- Gut microbiota and health
- Tryptophan and brain disorders
- Diet and metabolism studies
- Vagus Nerve Stimulation Research
- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Helicobacter pylori-related gastroenterology studies
Columbia University Irving Medical Center
2017-2020
Morgan Stanley Children's Hospital
2017-2019
Pediatrics and Genetics
2016
Columbia University
2011
Autism spectrum disorder (ASD) is an increasingly common behavioral condition that frequently presents with gastrointestinal (GI) disturbances. It not clear, however, how gut dysfunction relates to core ASD features. Multiple, rare hyperfunctional coding variants of the serotonin (5-HT) transporter (SERT, encoded by SLC6A4) have been identified in ASD. Expression most SERT variant (Ala56) mice increases 5-HT clearance and causes ASD-like behaviors. Here, we demonstrated Ala56-expressing...
Necrotizing enterocolitis (NEC), a gastrointestinal inflammatory disease of unknown etiology that may also affect the liver, causes great deal morbidity and mortality in premature infants. We tested hypothesis signaling molecules, which are endogenous to bowel, regulate severity intestinal hepatic damage an established murine NEC model. Specifically, we postulated mucosal serotonin (5-HT), is proinflammatory, would exacerbate experimental oxytocin (OT), present enteric neurons...