A5072966726- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Wnt/β-catenin signaling in development and cancer
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Fuel Cells and Related Materials
Amsterdam University Medical Centers
2022-2024
Vrije Universiteit Amsterdam
2023
Jilin University
2016-2018
Contractility of the adult heart relates to architectural degree sarcomeres in individual cardiomyocytes (CMs) and appears be inversely correlated with ability regenerate. In this study we utilized multiple imaging techniques follow sequence sarcomere disassembly during mitosis resulting cellular or nuclear division a source proliferating human pluripotent stem cell-derived (hiPSC-CMs). We observed that both mono- binuclear hiPSC-CMs give rise mononuclear daughter cells progeny. Within...
Background: Reactivation of the so-called fetal gene programs and pathways have been reported in failing hearts, however, it remains unclear whether this phenomenon is beneficial or detrimental to remaining functional myocardium. During cardiac development, orchestration these embryonic growth pathways, facilitate temporal stage-specific cell fate decisions such as required for specification various myocardial compartments. Previously, we demonstrated that molecular activation Wnt pathway...
Embryonic signaling pathways exert stage-specific effects during cardiac development, yet the precise signals for proliferation or maturation remain elusive. To uncover cues proliferation, we performed a combinatory cell-cycle screen insulin and glycogen synthase kinase-3 (GSK3) inhibition in spontaneously beating human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Our analysis subsequential downstream sarcomere gene expression analysis, molecular interventions identified...