A5071715589- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Biomedical and Chemical Research
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Biochemical Acid Research Studies
- Renal function and acid-base balance
- Anesthesia and Neurotoxicity Research
- Electroconvulsive Therapy Studies
- Hormonal Regulation and Hypertension
- Ion channel regulation and function
- Adrenal Hormones and Disorders
- Pharmacological Effects and Toxicity Studies
- Apelin-related biomedical research
- Healthcare cost, quality, practices
- Neurogenetic and Muscular Disorders Research
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Radiopharmaceutical Chemistry and Applications
- Liver Disease and Transplantation
- Vascular Tumors and Angiosarcomas
- Hereditary Neurological Disorders
- Medical Imaging and Pathology Studies
- Peripheral Neuropathies and Disorders
- Neuroendocrine regulation and behavior
Hôpitaux Iris Sud
2017-2024
Erasmus Hospital
1997-2023
Université Libre de Bruxelles
1993-2014
Hôpital de Jolimont
2000-2010
Rochester General Hospital
2007
University of Rochester
2007
Centre hospitalier régional de la Citadelle
2006
University Hospital Carl Gustav Carus
2006
Hôpital Raymond-Poincaré
2006
Sanofi (United States)
2006
Hyponatraemia, defined as a serum sodium concentration <135 mmol/l, is the most common disorder of body fluid and electrolyte balance encountered in clinical practice. It can lead to wide spectrum symptoms, from subtle severe or even life threatening, associated with increased mortality, morbidity length hospital stay patients presenting range conditions. Despite this, management remains problematic. The prevalence hyponatraemia widely different conditions fact that managed by clinicians...
Hyponatraemia, defined as a serum sodium concentration <135 mmol/l, is the most common disorder of body fluid and electrolyte balance encountered in clinical practice. It can lead to wide spectrum symptoms, from subtle severe or even life threatening, associated with increased mortality, morbidity length hospital stay patients presenting range conditions. Despite this, management remains problematic. The prevalence hyponatraemia widely different conditions fact that managed by clinicians...
Summary Background and objectives Vaptans (vasopressin V 2 -receptor antagonists) are a new approach for the treatment of hyponatremia. However, their indications remain to be determined, benefit compared with that usual treatments syndrome inappropriate antidiuretic hormone secretion (SIADH) have not been evaluated. This prospective, long-term study efficacy, tolerability, safety two oral vaptans those urea in patients SIADH. Design, setting, participants, & measurements Patients...
Hyponatremia in the intensive care unit (ICU) is most commonly related to inappropriate secretion of antidiuretic hormone (SIADH). Fluid restriction difficult apply these patients. We wanted report treatment hyponatremia with urea Two groups patients are reported. The first one represented by a retrospective study 50 consecutive mild treated urea. second group presented series 35 severe acquired outside hospital (≤ 115 mEq/L) who where isotonic saline and (0.5 1 g/kg/day), administered...
The effects of satavaptan (SR121463B), a novel long-acting orally active vasopressin V(2)-receptor antagonist, were investigated in patients with the syndrome inappropriate antidiuretic hormone secretion (SIADH). In first part this randomized, double-blind study, 34 treated (versus placebo) for up to 5 d and then during 23 open-label dosage-adjustment period. second long-term efficacy safety was assessed an trial at least 12 mo. Mean (+/-SD) serum sodium (SNa) levels before treatment 127 +/-...
Abrupt osmotic changes during rapid correction of chronic hyponatremia result in demyelinative brain lesions, but the sequence events linking to myelin loss is not yet understood. Here, a rat model demyelination syndrome, we found that massive astrocyte death occurred after hyponatremia, delineating regions future loss. Astrocyte caused disruption astrocyte-oligodendrocyte network, rapidly upregulated inflammatory cytokines genes, and increased serum S100B, which predicted clinical...
Brain myelinolysis could develop after excessive correction (ΔSNa > 20–25 mEq/l/24 hour [h]) of chronic hyponatremia; however, this neurological event is not recognized as a complication hypernatremia when arising from normonatremic baseline. Previous animal studies were unable to reproduce these brain lesions in acute increase serum sodium moderately hypernatremic levels. We hypothesize that produce dehydration and baseline requires more important osmotic gradient than starting hyponatremic...
Adequate protein folding is necessary for normal cell function and a tightly regulated process that requires proper intracellular ionic strength. In many types, imbalance between synthesis degradation can induce endoplasmic reticulum (ER) stress, which if sustained, in turn lead to death. nematodes, osmotic stress induces massive aggregation coupled with unfolded response ER stress. clinical practice, patients sustaining rapid correction of chronic hyponatremia are at risk demyelination...
ABSTRACT. It was recently demonstrated that renal failure and exogenous urea prevent myelinolysis induced by rapid correction of experimental hyponatremia. To determine why elevated blood levels favorably affect brain tolerance to osmotic stress, the changes in solute composition occur when chronic hyponatremia is rapidly corrected were studied rats with or without mercuric chloride-induced failure. After 48 h hyponatremia, brains azotemic nonazotemic animals became depleted sodium,...
Brain damage (myelinolysis) develops in hyponatraemia after a large increase serum sodium regardless of the currently available methods correction. However, preliminary study suggests that treatment with urea limits risks brain lesions rats. Benefits sustained high blood levels and mechanisms protection remain hypothetical.In first part study, hyponatraemic rats received repeated (i.p.) doses (2 g/kg b.w./6 h) leading to (urea+/-230 mg/dl). Neurologic outcome was compared correction by water...
Brain myelinolysis occurs after excessive correction (ΔSNa > 20 mEq/1/24 hours) of chronic hyponatremia. However, we showed recently that the mechanisms leading to brain remain reversible. Indeed, reinduction hyponatremia by water administration despite 12 hours sustained could prevent development demyelination in rats still asymptomatic at time. Whether this therapeutic maneuver be also beneficial with preexisting myelinolysis-related neurologic symptoms is unknown. Therefore evaluated here...
La hiponatremia se define como una concentración sérica de sodio <135 mmol/L y es el trastorno hidroelectrolítico más frecuente en la práctica clínica. puede causar un amplio espectro síntomas clínicos, desde sutiles hasta graves o incluso mortales, asocia con aumento morbimortalidad prolongación estancia hospitalaria. A pesar ello, manejo los pacientes sigue siendo problemático. prevalencia enfermedades muy diferentes su por diversos especialistas han fomentado existencia protocolos...