R. Madigan
A5037776035- Neutrino Physics Research
- Dark Matter and Cosmic Phenomena
- Astrophysics and Cosmic Phenomena
- Atomic and Subatomic Physics Research
- Particle Detector Development and Performance
- Analytical Chemistry and Sensors
- Molecular spectroscopy and chirality
- Advanced NMR Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Immune Response and Inflammation
- Supramolecular Chemistry and Complexes
- Antimicrobial Peptides and Activities
- Tryptophan and brain disorders
- Congenital heart defects research
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Heart Disease Studies
- Polydiacetylene-based materials and applications
- NMR spectroscopy and applications
- Ocular Surface and Contact Lens
- Heme Oxygenase-1 and Carbon Monoxide
- Electron Spin Resonance Studies
- Personality Disorders and Psychopathology
- Advanced Optical Sensing Technologies
The University of Texas at Arlington
2022-2024
Flinders Medical Centre
2024
Instituto de Instrumentación para Imagen Molecular
2023
Universitat Politècnica de València
2023
Universidad de Zaragoza
2023
Ben-Gurion University of the Negev
2023
Texas Christian University
2016
Rutgers, The State University of New Jersey
2011
Antibiotic resistance is a global public health issue, accelerated by the misuse and overuse of antibiotics. Microenvironment-targeted antimicrobial delivery an emergent promising strategy for selective antibiotic that targets site infections may reduce drug resistance. The local pH infected tissues can be primary target designing materials with pH-triggered activity. Given urgent need to combat bacterial in diseases elevated pH, we report on design synthesis new alkaline-responsive...
A bstract The NEXT experiment aims at the sensitive search of neutrinoless double beta decay in 136 Xe, using high-pressure gas electroluminescent time projection chambers. NEXT-White detector is first radiopure demonstrator this technology, operated Laboratorio Subterráneo de Canfranc. Achieving an energy resolution 1% FWHM 2.6 MeV and further background rejection by means topology reconstructed tracks, has been exploited beyond its original goals order to perform a neu- trinoless search....
If neutrinoless double beta decay is discovered, the next natural step would be understanding lepton number violating physics responsible for it. Several alternatives exist beyond exchange of light neutrinos. Some these mechanisms can distinguished by measuring phase-space observables, namely opening angle $\cos\theta$ among two electrons, and electron energy spectra, $T_1$ $T_2$. In this work, we study statistical accuracy precision in kinematic observables a future xenon gas detector with...
We investigate the performance of Opticks, an NVIDIA OptiX API 7.5 GPU-accelerated photon propagation compared with a single-threaded Geant4 simulation. compare simulations using improved model NEXT-CRAB-0 gaseous time projection chamber. Performance results suggest that Opticks improves simulation speeds by between $58.47\pm{0.02}$ and $181.39\pm{0.28}$ times relative to CPU-only these vary different types GPU CPU. A detailed comparison shows number detected photons, along their...
Calix[4]arenes are cyclic oligomers known for their unique molecular architecture that provides a versatile platform various applications in supramolecular chemistry. When strategically coupled with fluorescent molecules, recognition enables highly selective and sensitive chemosensors. The introduction of bridging groups at 1,3 phenolic positions within the calix[4]arene framework has potential to yield distinctive structural features enhanced functional properties. Despite opportunities,...
We describe and characterise the case of a 26-year-old female undergoing surgery for right-sided sinonasal alveolar rhabdomyosarcoma who developed profound, transient arginine vasopressin deficiency (AVP-D, formerly central diabetes insipidus (DI)) associated with anaesthesia. In this report, we development AVP-D serial copeptin paired urine serum osmolality measurements. Based on anaesthetic agent's profile literature, attribute presentation to propofol exposure. present description...
Abstract The search for neutrinoless double beta decay (0 νββ ) remains one of the most compelling experimental avenues discovery in neutrino sector. Electroluminescent gas-phase time projection chambers are well suited to 0 searches due their intrinsically precise energy resolution and topological event identification capabilities. Scalability ton- multi-ton masses requires readout large-area electroluminescent regions with fine spatial resolution, low radiogenic backgrounds, a scalable...
3-mercaptopropionate (3MPA) dioxygenase (MDO) is a mononuclear nonheme iron enzyme that catalyzes the O
Abstract Aim This exploratory study reports on borderline symptomatology within a sample of individuals at clinical high risk for psychosis (CHR‐P) through validated, self‐report instrument, the short version Borderline Symptom List (BSL‐23). Methods The consisted 44 help‐seeking CHR‐P youth (ages 14–29 years) who completed an initial evaluation specialized clinic psychosis‐risk. Results mean BSL‐23 score was 1.5 ( SD = 1.0, range 0.1–4.0). Higher scores were strongly associated with greater...
The NEXT experiment aims at the sensitive search of neutrinoless double beta decay in $^{136}$Xe, using high-pressure gas electroluminescent time projection chambers. NEXT-White detector is first radiopure demonstrator this technology, operated Laboratorio Subterr\'aneo de Canfranc. Achieving an energy resolution 1% FWHM 2.6 MeV and further background rejection by means topology reconstructed tracks, has been exploited beyond its original goals order to perform a search. analysis considers...
Abstract The imaging of individual Ba 2+ ions in high pressure xenon gas is one possible way to attain background-free sensitivity neutrinoless double beta decay and hence establish the Majorana nature neutrino. In this paper we demonstrate selective single ion inside a high-pressure environment. chelated with molecular chemosensors are resolved at gas-solid interface using diffraction-limited system scan area 1 × cm 2 located 10 bar gas. This form microscopy represents key ingredient...
Abstract We present a tunable metal ion beam that delivers controllable currents in the picoamp range for testing of dry-phase sensors. Ion beams are formed by sequential atomic evaporation and single or multiple electron impact ionization, followed acceleration into sensing region. Controllability ionic charge state is achieved through tuning electrode potentials influence retention time ionization Barium, lead, cadmium samples have been used to test system, with identified quantified using...
Fluorophores containing azacrown ether ionophores can be assembled as particularly powerful, sensitive, and selective turn-on chemosensors, due to their well-known size specificity of the binding domain. Here we quantify capability three commercially available marketed for biologically useful K+ sensing probes Ba2+ ions. Results are presented from both bulk spectrofluorimetry in aqueous solution, well at single molecule level using fluorescence microscopy.
The search for neutrinoless double beta decay ($0\nu\beta\beta$) remains one of the most compelling experimental avenues discovery in neutrino sector. Electroluminescent gas-phase time projection chambers are well suited to $0\nu\beta\beta$ searches due their intrinsically precise energy resolution and topological event identification capabilities. Scalability ton- multi-ton masses requires readout large-area electroluminescent regions with fine spatial resolution, low radiogenic...
Noble element time projection chambers are a leading technology for rare event detection in physics, such as dark matter and neutrinoless double beta decay searches. Time typically assign position the drift direction using relative timing of prompt scintillation delayed charge collection signals, allowing reconstruction an absolute direction. In this paper, alternate methods assigning distance via quantification electron diffusion pure high pressure xenon gas chamber explored. Data from...
Calix[4]arenes are cyclic oligomers known for their unique molecular architecture that provides a versatile platform various applications in supramolecular chemistry, host-guest interactions, and recognition detection when coupled to fluorescent molecules. The introduction of bridging groups at the 1,3 phenols within calix[4]arene framework has potential yield distinctive structural features enhanced functional properties. We used multi-faceted approach, employing combination experimental...
Fluorophores containing azacrown ether ionophores can be assembled as particularly powerful, sensitive, and selective turn-on chemosensors, due to their well-known size specificity of the binding domain. Here we quantify capability three commercially available marketed for biologically useful K+ sensing probes Ba2+ ions. Results are presented from both bulk spectrofluorimetry in aqueous solution, well at single molecule level using fluorescence microscopy.