A5047060930- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Advanced NMR Techniques and Applications
- Synthesis and Catalytic Reactions
- Molecular spectroscopy and chirality
- Analytical Chemistry and Chromatography
- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- NMR spectroscopy and applications
- Sulfur-Based Synthesis Techniques
- Catalytic Alkyne Reactions
- Polydiacetylene-based materials and applications
- Supramolecular Self-Assembly in Materials
- Carbohydrate Chemistry and Synthesis
- Oxidative Organic Chemistry Reactions
- Vanadium and Halogenation Chemistry
- Supramolecular Chemistry and Complexes
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
The University of Texas at Arlington
2015-2024
A variety of allylic acetates and derivatives were synthesized by an efficient two-step protocol that employs readily available terminal alkenes as starting materials. This method is highly regio- stereoselective, affording the linear (E)- isomer sole adduct. process tolerates several functional groups including halogen-containing molecules, it general for weak oxygen, carbon, nitrogen, sulfur nucleophiles. Furthermore, adducts obtained in good to excellent yields.
Calix[4]arenes are cyclic oligomers known for their unique molecular architecture that provides a versatile platform various applications in supramolecular chemistry. When strategically coupled with fluorescent molecules, recognition enables highly selective and sensitive chemosensors. The introduction of bridging groups at 1,3 phenolic positions within the calix[4]arene framework has potential to yield distinctive structural features enhanced functional properties. Despite opportunities,...
Twelve new azole compounds were synthesized through an ene reaction involving methylidene heterocycles and phenylmaleimide, producing four oxazoles, five thiazoles, one pyridine derivative, ethyl glyoxylate for oxazole a thiazole compound. The twelve azoles have stereogenic center in their structure. Hence, method to separate the enantiomeric pairs, must be provided if any further study of chemical pharmacological importance these is accomplished. Six chiral stationary phases assayed: based...
Self-assembled peptides are an emerging family of biomaterials that show great promise for a range biomedical and biotechnological applications. Introducing tuning the pH-responsiveness assembly is highly desirable improving their biological activities. Inspired by proteins with internal ionizable residues, we report simple but effective approach to constructing pH-responsive peptide containing unnatural ionic amino acids aliphatic tertiary amine side chain. Through combined experimental...
In the course of studying Diels–Alder reactions 4-vinylimidazoles with N-phenylmaleimide, it was discovered that they engage in cycloaddition at room temperature to give high yields initial cycloadduct as a single stereoisomer. certain cases, product precipitated out reaction mixture and could be isolated by simple filtration, thereby avoiding issues aromatization observed during chromatographic purification. Given these results, intramolecular variants using doubly activated dienophiles...
Abstract Eleven racemic ethanolamine derivatives were prepared, and their enantiomers separated using liquid chromatography with various chiral columns. These included vicinal amino alcohols, β‐hydroxy ureas, thioureas, guanidines, all of which are present in many active pharmaceutical ingredients. The screening study was performed six stationary phase containing columns, including four recently introduced superficially porous particles bonded two macrocyclic glycopeptides, a cyclodextrin...
Abstract Bromination of alkenes (I) give the corresponding dibromides which are further converted into linear (E)‐allylic compounds upon treatment with various nucleophiles.
Calix[4]arenes are cyclic oligomers known for their unique molecular architecture that provides a versatile platform various applications in supramolecular chemistry, host-guest interactions, and recognition detection when coupled to fluorescent molecules. The introduction of bridging groups at the 1,3 phenols within calix[4]arene framework has potential yield distinctive structural features enhanced functional properties. We used multi-faceted approach, employing combination experimental...