ADVERTISEMENT RETURN TO ISSUEPREVFEATURESNEXTChiral Recognition MechanismsAlain BerthodCite this: Anal. Chem. 2006, 78, 7, 2093–2099Publication Date (Web):April 1, 2006Publication History Published online1 April 2006Published inissue 1 2006https://doi.org/10.1021/ac0693823RIGHTS & PERMISSIONSArticle Views5393Altmetric-Citations261LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions...

The structurally related glycopeptide antibiotics vancomycin, ristocetin A, and teicoplanin can all be used as chiral selectors in capillary electrophoresis (CE). Both experimental modeling studies were done to elucidate their similarities differences. There are identifiable morphological differences the aglycon macrocyclic portions of these three compounds. In addition, there other structural distinctions that affect CE enantioselectivity, migration times, efficiency. Teicoplanin is most...

For this study, we used the macrocyclic antibiotic teicoplanin, a molecule consisting of an aglycone peptide "basket" with three attached carbohydrate (sugar) moieties. The sugar units were removed and was purified. Two chiral stationary phases (CSPs) prepared in similar way, one native teicoplanin other aglycone. Twenty-six compounds evaluated on two CSPs seven RPLC mobile polar organic phases. 13 amino acids or structurally related (including DOPA, folinic acid, etc.) (such as carnitine,...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple enantioselective retention mechanisms on derivatized cyclodextrin gas chromatographic chiral stationary phases.Alain. Berthod, Weiyong. Li, and Daniel W. ArmstrongCite this: Anal. Chem. 1992, 64, 8, 873–879Publication Date (Print):April 15, 1992Publication History Published online1 May 2002Published inissue 15 April 1992https://pubs.acs.org/doi/10.1021/ac00032a009https://doi.org/10.1021/ac00032a009research-articleACS PublicationsRequest...

Abstract Countercurrent chromatography (CCC) is a generic term covering all forms of liquid-liquid that use support-free liquid stationary phase held in place by simple centrifugal or complex force field. Biphasic systems are used with one being the and other mobile phase. Although initiated almost 30 years ago, CCC lacked reliable columns. This changing now, newly designed centrifuges appearing on market make excellent review focuses advantages addresses chromatographic theory CCC. The main...

Countercurrent chromatography (CCC) is a liquid technique with stationary phase. Taking advantage of the nature phase, it possible to perform unique operations not in classical solid It easy avoid any solute-irreversible absorption CCC column. If retention volumes solutes become too high, dual mode will be used. The roles phases are reversed. phase becomes mobile and column started again. elute rapidly what was previously theoretical basis dual-mode method recalled. discontinuous method....

Abstract Salts with low melting points, also termed room‐temperature ionic liquids, can be used as matrices in matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF). They have great vacuum stability, and dissolve polar apolar solutes including carbohydrates, biological oligomers proteins. The liquids give much more homogeneous sample solutions compared solid matrices. We demonstrate the usefulness of using to determine molecular weight DNA by direct TOF mass spectrometric...

Elution−extrusion countercurrent chromatography (EECCC) takes full advantage of the liquid nature stationary phase in CCC by combining regular chromatographic elution with stationary-phase extrusion. EECCC is shown to be a three-stage process consisting classical (I), sweeping (II), and extrusion (III). After only two column volumes solvent, it rapidly yields high-resolution chromatogram that covers an extended polarity range solutes. As hydrophilicity/lipophilicity balance crucial...

Room temperature ionic liquids (RTIL) are molten salts starting to be used as nonmolecular solvents in separation methods mainly for their extremely low vapor pressure and thermal stability. RTILs formed by an anion associated a cation. This intrinsic structure gives them dual nature. When additives RPLC mobile phases enhance basic compound separation, lose particular physicochemical properties become just salts. However, given RTIL is not equivalent another one made with the same It shown...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicellar liquid chromatography, adsorption isotherms of two ionic surfactants on five stationary phasesAlain. Berthod, Ines. Girard, and Colette. GonnetCite this: Anal. Chem. 1986, 58, 7, 1356–1358Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/ac00298a019https://doi.org/10.1021/ac00298a019research-articleACS PublicationsRequest reuse permissionsArticle...

Abstract: Micellar liquid chromatography (MLC) is an efficient alternative to conventional reversed–phase with hydro‐organic mobile phases. Almost three decades of experience have resulted in increasing production analytical applications. Current concern about the environment also reveals MLC as interesting technique for "green" chemistry because it uses phases containing 90% or more water. These micellar a low toxicity and are not producing hazardous wastes. After rapid overview two first...