A5035471947- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Pancreatic and Hepatic Oncology Research
- Carbohydrate Chemistry and Synthesis
- Aldose Reductase and Taurine
- Alzheimer's disease research and treatments
- Cannabis and Cannabinoid Research
- Cellular transport and secretion
- Reproductive Biology and Fertility
- Systemic Lupus Erythematosus Research
- Parkinson's Disease Mechanisms and Treatments
- Helicobacter pylori-related gastroenterology studies
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Prenatal Substance Exposure Effects
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
Cancer Hospital of Shantou University Medical College
2023-2024
Shantou University
2022-2024
Shantou University Medical College
2022-2023
Tohoku Medical and Pharmaceutical University
2021-2023
Dalian Medical University
2019-2022
Komatsu (Japan)
2021
Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective response. N-glycosylation is essential for FSH receptor (FSHR). Core fucosylation catalyzed by fucosyltransferase 8 (FUT8) the most common N-glycosylation. level changes between individuals and plays important roles in multiple physiological pathological conditions. This study aims elucidate significance of FUT8 modulate FSHR function...
Core fucosylation catalyzed by core fucosyltransferase (Fut8) contributes to the progressions of epithelial ovarian cancer (EOC). Copper transporter 1 (CTR1), which contains one N‐glycan on Asn 15 , mediates cellular transport cisplatin (cDDP), and plays an important role in process cDDP‐resistance EOC. In present study, we found that level elevated significantly sera cDDP‐treated EOC patients. The vitro assays also indicate CTR1 was upregulated cDDP‐resistant A2780CP cells compared...
The phenomenon of multidrug resistance (MDR) is called chemoresistance with respect to the treatment cancer, and it continues be a major challenge. role N-glycosylation in chemoresistance, however, remains poorly understood. Here, we established traditional model for adriamycin K562 cells, which are also known as K562/adriamycin-resistant (ADR) cells. Lectin blot, mass spectrometry, RT-PCR analysis showed that expression levels N-acetylglucosaminyltransferase III (GnT-III) mRNA its products,...
N-Linked glycosylation and O-linked N-acetylglucosamine (O-GlcNAc) are important protein post-translational modifications that orchestrated by a diverse set of gene products. Thus far, the relationship between these two types has remained elusive, it is unclear whether one influences other via UDP-GlcNAc, which common donor substrate. Theoretically, decrease in O-GlcNAcylation may increase products GlcNAc-branched N-glycans. In this study, examination lectin blotting, HPLC, mass spectrometry...
Abstract Systemic lupus erythematosus (SLE) is a complex multi-system autoimmune disease. Detection of anti-nuclear antibodies (ANA) fundamental for the diagnosis SLE. In present study, we found that level core fucosylation catalyzed by α1,6-fucosyltransferase (Fut8) markedly up-regulated on immunoglobulin G (IgG) in sera SLE patients detected Aspergillus oryzae lectin (AOL) blot. sandwich Dot enzyme-linked immunosorbent assay (Dot-ELISA), was also significantly increased from with higher...
Fucosylation, an important post-translational modification, is closely related to the development of tumors. In microenvironment lung cancer, expression PD-L1 and fucosylation abnormally upregulated. However, correlation between its in adenocarcinoma (LUAD) remains unclear. The GDP-fucose transporter (GFT) a key molecule cellular fucosylation. To explore expression, we knocked out GFT-encoding gene SLC35C1 mouse Lewis cells human H1299 cells. Loss impaired phosphorylation EGFR downstream...
Abstract Taurine (Tau) is a special sulphur‐containing amino acid and has been widely used as dietary supplement. Although Tau exists in lymphocytes large quantities, the physiological significance of to modulate human immunity unknown. In present study, we first found that regulates B‐cell receptor (BCR)‐mediated signal transduction induces B cells activation. The IgG production mice after ovalbumin immunization was also increased by administration. Moreover, isothermal titration...