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Hayk Saryan

ORCID: 0009-0003-0913-3264
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About
Contact & Profiles
A5041964384
Research Areas
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Galectins and Cancer Biology
  • T-cell and B-cell Immunology
  • Immunodeficiency and Autoimmune Disorders

University of California, Irvine
 2022-2024

 Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching
OPENALEX - Publications 
Haik Mkhikian Ken Hayama Khachik Khachikyan Carey Li Raymond Zhou and 13 more Judy Pawling Suzi Klaus Phuong Q. N. Tran Kim M. Ly Andrew D. Gong Hayk Saryan Jasper L. Hai David Grigoryan Philip L. Lee Barbara L. Newton Manuela Raffatellu James W. Dennis Michael Demetriou

10.1038/s43587-022-00187-y article EN Nature Aging 2022-03-18
 N-Glycan Branching Regulates BTLA Opposite to PD-1 to Limit T Cell Hyperactivity Induced by Branching Deficiency
OPENALEX - Publications 
Haik Mkhikian Raymond Zhou Hayk Saryan C. Sanchez A Balakrishnan and 3 more Justin Dang Christie Mortales Michael Demetriou

Abstract N-glycan branching is a potent and multifaceted negative regulator of proinflammatory T cell B function. By promoting multivalent galectin–glycoprotein lattice formation at the surface, regulates clustering and/or endocytosis TCR complex (TCR+CD4/CD8), CD45, CD25, BCR, TLR2 TLR4 to inhibit activation/proliferation TH1 TH17 over TH2 induced regulatory responses. In addition, promotes surface retention growth inhibitory receptor CTLA-4. However, role in regulating levels other...

10.4049/jimmunol.2300568 article EN The Journal of Immunology 2024-09-13
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