A5045343636- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Epilepsy research and treatment
- Invertebrate Immune Response Mechanisms
- Retinal and Macular Surgery
- Immunodeficiency and Autoimmune Disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- MicroRNA in disease regulation
- Retinopathy of Prematurity Studies
- Glaucoma and retinal disorders
- Mass Spectrometry Techniques and Applications
- Ion-surface interactions and analysis
- Insect symbiosis and bacterial influences
- Ocular and Laser Science Research
- Escherichia coli research studies
- Musculoskeletal synovial abnormalities and treatments
- Molecular Biology Techniques and Applications
- Lysosomal Storage Disorders Research
- Otolaryngology and Infectious Diseases
University of California, Irvine
2011-2024
Vanderbilt University
2019-2024
University of California, Los Angeles
2021
Loyola Marymount University
2021
Banaras Hindu University
2021
Mattel Children's Hospital
2015-2017
National Eye Institute
2016-2017
National Institutes of Health
2017
Icahn School of Medicine at Mount Sinai
2012
New York University
2008
How environmental factors combine with genetic risk at the molecular level to promote complex trait diseases such as multiple sclerosis (MS) is largely unknown. In mice, N-glycan branching by Golgi enzymes Mgat1 and/or Mgat5 prevents T cell hyperactivity, cytotoxic T-lymphocyte antigen 4 (CTLA-4) endocytosis, spontaneous inflammatory demyelination and neurodegeneration, latter pathologies characteristic of MS. Here we show that MS modulators converge alter N-glycosylation CTLA-4 surface...
Essential biological systems employ self-correcting mechanisms to maintain cellular homeostasis. Mammalian cell function is dynamically regulated by the interaction of surface galectins with branched N-glycans. Here we report that N-glycan branching deficiency triggers Golgi generate bioequivalent N-glycans preserve galectin-glycoprotein interactions and Galectins bind N-acetyllactosamine (LacNAc) units within initiated from UDP-GlcNAc medial-Golgi enzymes as well trans-Golgi poly-LacNAc...
Summary Objective Although the link between vigabatrin ( VGB ) and retinotoxicity is well known, little attention has been focused on risk of ‐associated brain abnormalities magnetic resonance imaging MRI VABAM ), namely reversible—and largely asymptomatic—signal changes in thalami, basal ganglia, brainstem tegmentum, cerebellar nuclei. Using a large infantile spasms cohort, we set out to identify predictors these phenomena. Methods Children with were retrospectively identified. Brain...
Epidemiologic studies correlate low vitamin C intake with bone loss. The genetic deletion of enzymes involved in de novo synthesis mice, likewise, causes severe osteoporosis. However, very few have evaluated a protective role this dietary supplement on the skeleton. Here, we show that ingestion prevents low-turnover loss following ovariectomy mice. We prevention areal mineral density and micro-CT parameters results from stimulation formation, demonstrable vivo by histomorphometry, marker...
TopicThis scoping review summarizes AI reporting in ophthalmology literature, respect to model development and validation. We characterize the state of transparency studies prospectively validating models for disease classification.Clinical RelevanceUnderstanding what elements authors currently describe regarding their may aid future standardization reporting. This highlights need facilitate critical appraisal prior clinical implementation, minimize bias inappropriate use. Transparent can...
Abstract N-glycan branching is a potent and multifaceted negative regulator of proinflammatory T cell B function. By promoting multivalent galectin–glycoprotein lattice formation at the surface, regulates clustering and/or endocytosis TCR complex (TCR+CD4/CD8), CD45, CD25, BCR, TLR2 TLR4 to inhibit activation/proliferation TH1 TH17 over TH2 induced regulatory responses. In addition, promotes surface retention growth inhibitory receptor CTLA-4. However, role in regulating levels other...
Abstract Micropipette tip (tip) pipetting accuracy and precision are functions of manufacture consistency, morphological variation, retained inner wall particulate matter. Irregular surfaces matter cause inaccuracy. Washed unwashed tips from seven manufacturers were compared using weight by difference (six), microscopic Luxol Fast Blue staining (seven), matrix‐assisted laser desorption/onization time‐of‐flight (MALDI‐TOF) mass spectrometry (six). Photomicrographs revealed irregularity...
Abstract Aging is associated with a decline in immune function, increasing the frequency and severity of infection elderly. We have previously shown that Asparagine (N) – linked protein glycosylation critical negative regulator T cell immunity both mice humans. Here we report N-glycan branching cells increases age, leading to hypo-activity increased susceptibility infection. Reducing rejuvenates activation, proliferation pro-inflammatory TH17 over anti-inflammatory Treg differentiation aged...
A 54-year old female with longstanding metastatic breast cancer was referred for management of choroidal metastases. She first treated external beam radiotherapy and experienced some response before later suffering progression her eye disease. We then using full fluence Photodynamic therapy (PDT) Verteporfin, which resulted in regression lesions until she passed away due to other illnesses. This is the documented successful application PDT metastasis from a primary refractory radiotherapy.