A5083298376- Allergic Rhinitis and Sensitization
- Inflammasome and immune disorders
- Nasal Surgery and Airway Studies
- Olfactory and Sensory Function Studies
- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Otitis Media and Relapsing Polychondritis
- IL-33, ST2, and ILC Pathways
Beijing Tongren Hospital
2022-2025
Capital Medical University
2022-2025
Beijing Institute of Neurosurgery
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Platelet-activating factor (PAF) mediates nasal congestion and rhinorrhea by affecting vascular permeability, but the underlying mechanisms remain unclear. Here, we sought to explore effect of PAF on epithelial barrier in chronic rhinosinusitis with polyps (CRSwNP). Human cells (hNECs) were pre-treated Apafant, a receptor (PAFR) inhibitor, or MCC950, an NOD-like protein 3 (NLRP3) inflammasome before stimulation. The function was assessed measuring transepithelial electrical resistance (TER)...
Abstract Background Studies have independently indicated that eosinophils and histone deacetylases (HDACs) may compromise the integrity of epithelial barrier in nasal polyps; however, underlying mechanisms are not clear. In this study, we aimed to investigate role eosinophilia HDACs regulation tight junctions (TJs) chronic rhinosinusitis with polyps (CRSwNP) patients. Methods Expression mRNAs proteins TJs biopsy specimens air‐liquid interface (ALI) human cell cultures (HNECs) from...
MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in single spray, is superior to alone relieving symptoms improving the quality of life patients with allergic rhinitis. In this study, we evaluated whether effect AzeFlu, generic drug manufactured from China, equivalent that MP-AzeFlu. total, 679 were recruited for multicentre, randomized, double-blind, original drug-controlled, parallel-group clinical trial. Overall,...