A5116585297- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- PARP inhibition in cancer therapy
Universitat de Barcelona
2025
Barcelona Supercomputing Center
2025
Centre for Genomic Regulation
2025
Vall d'Hebron Institute of Oncology
2025
Abstract Homologous recombination deficiency (HRD) contributes to genomic instability and leads sensitivity poly ADP-ribose polymerase inhibitors (PARPi). HRD also activates the cyclic GMP–AMP synthase (cGAS)-STimulator of INterferon Genes (STING)-Interferon (IFN) pathway, highlighting need understand impact cGAS-STING-IFN signaling on PARPi efficacy. In this study, we analyzed a cohort thirty-five breast cancer (BC) patient-derived xenografts (PDX) mouse-derived allografts (MDA). correlated...
Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human largely derived from transcriptomic data of individuals with European ancestry, introducing potential biases that remain uncharacterized. Here, we generate over 800 million full-length reads long-read RNA-seq in 43 lymphoblastoid cell line samples eight genetically-diverse populations build a cross-ancestry annotation. We show transcripts...