A5010510242- Immune Response and Inflammation
- Influenza Virus Research Studies
- Immune Cell Function and Interaction
- Fatty Acid Research and Health
- Renin-Angiotensin System Studies
- Antimicrobial Resistance in Staphylococcus
- Pulmonary Hypertension Research and Treatments
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Antimicrobial Peptides and Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- interferon and immune responses
Children's Hospital of Pittsburgh
2024-2025
Universidade Federal de Minas Gerais
2019-2024
Abstract Influenza virus infects millions each year, contributing greatly to human morbidity and mortality. Upon viral infection, pathogen-associated molecular patterns activate pattern recognition receptors on host cells, triggering an immune response. The CD209 protein family, homologs of DC-SIGN (dendritic cell–specific intercellular adhesion molecule 3–grabbing nonintegrin), is thought modulate responses viruses. effects the mouse functional homolog CD209d/e lung during influenza...
Abstract Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition pathogen-associated molecular patterns through pattern-recognition receptors crucial for eliminating microorganisms such as S. aureus. DC-SIGN (CD209) receptor that binds to broad range pathogens, promoting phagocytosis. Here we aimed study role mouse homologues DC-SIGN, CD209d/e, in methicillin-resistant (MRSA) pulmonary infection model. CD209d/e−/− wild-type C57BL/6 mice...
Abstract Idiopathic pulmonary fibrosis is characterized by aberrant fibroblast activation and excessive collagen deposition that may eventually lead to organ dysfunction. Lung frequently observed in cancer patients undergoing bleomycin (BLM) treatment. Therefore, BLM instillation mice the most frequent model used investigate fibrosis. Angiotensin 1–7 [Ang-(1-7)] a heptapeptide with anti-inflammatory proresolving activity. Here, we studied effects of preventive therapeutic oral administration...
<title>Abstract</title> Objective and design: Here, we evaluated whether a synthetic lipoxin mimetic, designated AT-01-KG, would improve the course of influenza A infection in murine model. Treatment: Mice were infected with A/H1N1 treated AT-01-KG (1.7 mg/kg/day, i.p.) at day 3 post-infection. Methods Mortality rate was assessed up to 21 inflammatory parameters days 5 7. Results attenuated mortality, reducing leukocyte infiltration lung damage 7 is Formyl Peptide Receptor 2 (designated...
Abstract Every year millions of people are infected with influenza, which can be complicated by secondary bacterial pneumonia. One factor that may contribute to increased susceptibility infection is the modulation inflammatory cytokines. NF erythroid 2–related 2 (Nrf2) has been shown a master regulator antioxidant response and various To test role Nrf2 during viral–bacterial superinfection, we used mouse model influenza–Staphylococcus aureus superinfection wild-type (WT) or Nrf2-deficient...