A5086215329- Nuclear Structure and Function
- Immune cells in cancer
- Cancer Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Inflammatory Myopathies and Dermatomyositis
- interferon and immune responses
- RNA modifications and cancer
- Genital Health and Disease
Centre for Genomic Regulation
2023
ABSTRACT The physical microenvironment regulates cell behaviour. However, whether confinement rewires the subcellular localisation of organelles and affect metabolism is unknown. Proteomics analysis revealed that cellular induces a strong enrichment mitochondrial proteins within nuclear compartment. High-resolution microscopy confirmed mechanical leads to rapid re-localisation mitochondria periphery. This nuclear-mitochondrial proximity mediated by an endoplasmic reticulum-based net entraps...
SUMMARY Metastasis is responsible for nearly 90% of all cancer-related deaths. Despite global efforts to prevent aggressive tumours, cancers such as pancreatic ductal adenocarcinoma (PDAC) are poorly diagnosed in the primary stage, resulting lethal metastatic disease. RAS mutations known promote tumour spread, with mutant KRAS present up cases. Until recently, remained untargeted and, despite recent development inhibitors, results show that cells develop resistance. Another strategy...