A5048070424- Dementia and Cognitive Impairment Research
- Bioinformatics and Genomic Networks
- Blood Pressure and Hypertension Studies
- Genetic Associations and Epidemiology
- Alzheimer's disease research and treatments
- Topic Modeling
- Ginkgo biloba and Cashew Applications
- Machine Learning in Healthcare
- Cerebrovascular and Carotid Artery Diseases
- Natural Language Processing Techniques
- Diabetes Treatment and Management
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Mitochondrial Function and Pathology
- Gaze Tracking and Assistive Technology
- Circadian rhythm and melatonin
- interferon and immune responses
- EEG and Brain-Computer Interfaces
- Cell Adhesion Molecules Research
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Nuclear Structure and Function
- ATP Synthase and ATPases Research
- Health, Environment, Cognitive Aging
- Renin-Angiotensin System Studies
King Abdulaziz University
2024
University of Oxford
2021-2024
Artificial Intelligence in Medicine (Canada)
2024
Warneford Hospital
2022
Nanyang Technological University
2020
Manipal Academy of Higher Education
2019
Circulating plasma proteins play key roles in human health and can potentially be used to measure biological age, allowing risk prediction for age-related diseases, multimorbidity mortality. Here we developed a proteomic age clock the UK Biobank (n = 45,441) using platform comprising 2,897 explored its utility predict major disease morbidity mortality diverse populations. We identified 204 that accurately chronological (Pearson r 0.94) found aging was associated with incidence of 18 chronic...
Introduction Type 2 diabetes is a risk factor for dementia and Parkinson’s disease (PD). Drug treatments diabetes, such as metformin, could be used novel these neurological conditions. Using electronic health records from the USA (OPTUM EHR) we aimed to assess association of metformin with all-cause dementia, subtypes PD compared sulfonylureas. Research design methods A new user comparator study was conducted in patients ≥50 years old who were users or sulfonylureas between 2006 2018....
Eye tracking is a widely used tool for behavioral research in the field of psychology. With technological advancement, we now have specialized eye-tracking devices that offer high sampling rates, up to 2000 Hz, and allow measuring eye movements with accuracy. They also spatial resolution, which enables recording very small movements, like drifts microsaccades. Features parameters interest characterize need be algorithmically extracted from raw data as most trackers identify only basic...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Background and objective Blood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (AD). Previous research has applied traditional machine learning (ML) analyze plasma omics data search for potential biomarkers, but the most modern ML methods based on deep however been scarcely explored. In current study, we aim harness power of state-of-the-art neural networks (NNs) proteins that predict amyloid, tau, neurodegeneration (AT[N]) pathologies in AD....
Hypertension is a well-established risk factor for cognitive impairment, brain atrophy, and dementia. However, the relationship of other types hypertensions, such as isolated hypertension on health its comparison to systolic-diastolic (where systolic diastolic measures are high), still relatively unknown. Due increased prevalence, it important investigate impact help understand potential decline future dementia risk. In this study, we compared variety global between participants with those...
Abstract Background In India, anemia is widely researched in children and women of reproductive age, however, studies older populations are lacking. Given the adverse effect on cognitive function dementia this population group warrants further study. The Longitudinal Ageing Study India – Harmonized Diagnostic Assessment Dementia (LASI-DAD) dataset contains detailed measures to allow a better understanding anaemia as potential risk factor for dementia. Method 2,758 respondents from LASI-DAD...
Abstract Augmenting traditional genome-wide association studies (GWAS) with advanced machine learning algorithms can allow the detection of novel signals in available cohorts. We introduce “genome-wide neural networks (GWANN)” a approach that uses (NNs) to perform gene-level study family history Alzheimer’s disease (AD). In UK Biobank, we defined cases (n = 42 110) as those AD or and sampled an equal number controls. The data was split into 80:20 ratio training testing samples, GWANN trained...
The entry of large language models (LLMs) into research and commercial spaces has led to a trend ever-larger models, with initial promises generalisability, followed by widespread desire downsize create specialised without the need for complete fine-tuning, using Parameter Efficient Fine-tuning (PEFT) methods. We present an investigation suitability different PEFT methods clinical decision-making tasks, across range model sizes, including extremely small as few $25$ million parameters. Our...
Abstract We performed a genome-wide association study of 143,067 highly polymorphic short tandem repeats (STRs) with MRI brain grey matter volumes (GMVs) on 10,702 UK Biobank (UKB) participants, including 8,751 in the discovery stage and 1,701 replication analysis. STRs’ repeat lengths were estimated from UKB whole-genome sequencing data using Expansion Hunter software. A total 262 STRs reached significance analyses autosomal sex chromosomes’ ( P = 6.9 × 10 −8 ) -GMVs. Replication second...
ABSTRACT The physical microenvironment regulates cell behaviour. However, whether confinement rewires the subcellular localisation of organelles and affect metabolism is unknown. Proteomics analysis revealed that cellular induces a strong enrichment mitochondrial proteins within nuclear compartment. High-resolution microscopy confirmed mechanical leads to rapid re-localisation mitochondria periphery. This nuclear-mitochondrial proximity mediated by an endoplasmic reticulum-based net entraps...
Summary Augmenting traditional genome wide association studies (GWAS) with advanced machine learning algorithms can allow the detection of novel signals in available cohorts. We introduce “Genome neural networks (GWANN)”, a approach that uses (NNs) to perform gene-level study family history Alzheimer’s disease (AD). In UK Biobank, we defined cases (n=42,110) as those AD or and sampled an equal number controls. The data was split into 80:20 ratio training testing samples, GWANN trained on...
Hypertension is a well-established risk factor for cognitive impairment, brain atrophy, and dementia. However, the relationship of other types hypertension, such as, isolated hypertension on health its comparison to systolic-diastolic (where systolic diastolic measures are high), still relatively unknown. Due increased prevalence, it important investigate impact help understand potential decline future dementia risk. In this study, we compared variety global between participants with those...
Abstract Background Hypertension is a well‐established risk factor for dementia and antihypertensive treatments could be important disease prevention. Observational animal studies suggest Angiotensin‐Converting Enzyme Inhibitors (ACEIs) are associated with reduced whereas genetic show these drugs increase risk. One plausible explanation of this heterogeneity that not all ACEIs cross the blood–brain barrier (BBB) their association may depend on whether or specific molecule crosses blood brain...
SUMMARY Metastasis is responsible for nearly 90% of all cancer-related deaths. Despite global efforts to prevent aggressive tumours, cancers such as pancreatic ductal adenocarcinoma (PDAC) are poorly diagnosed in the primary stage, resulting lethal metastatic disease. RAS mutations known promote tumour spread, with mutant KRAS present up cases. Until recently, remained untargeted and, despite recent development inhibitors, results show that cells develop resistance. Another strategy...
Introduction: Type 2 diabetes is a risk factor for dementia and Parkinson's disease (PD). Drug treatments diabetes, such as metformin, could be used potential novel these neurological conditions. Using medical records from the USA (OPTUM) we aimed to assess association of metformin with all cause dementia, subtypes, PD compared sulfonylureas. Research Design Methods: A new user comparator study design was conducted in patients >50 years old who were users or sulfonylureas between...
Abstract Background Hypertension is a well‐established risk factor for cognitive impairment, brain atrophy and dementia. Isolated hypertension where either systolic or diastolic blood pressure high the other measure normal. It unknown impact of isolated on how it compares to non (NIH). Therefore important investigate help understand its future dementia decline. We investigated relationships between volumes using largest cohort healthy individuals from United Kingdom. Method Using UK Biobank...