A5028168081- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Dermatology and Skin Diseases
- Advanced Malware Detection Techniques
- Adversarial Robustness in Machine Learning
- Neural dynamics and brain function
- Myofascial pain diagnosis and treatment
- Physical Unclonable Functions (PUFs) and Hardware Security
- Neuroscience and Neural Engineering
- Electrochemical Analysis and Applications
- Urticaria and Related Conditions
- Parkinson's Disease and Spinal Disorders
- Cholinesterase and Neurodegenerative Diseases
- Hereditary Neurological Disorders
- Cancer Treatment and Pharmacology
- Pharmacological Effects of Natural Compounds
- Neurological disorders and treatments
- Herbal Medicine Research Studies
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Autoimmune Bullous Skin Diseases
University of California, San Diego
2012-2024
Microsoft (United States)
2018
Dokkyo Medical University
2013
Beta-amyloid (Aβ) depresses excitatory synapses by a poorly understood mechanism requiring NMDA receptor (NMDAR) function. Here, we show that increased PSD-95, major synaptic scaffolding molecule, blocks the effects of Aβ on synapses. The protective effect persists in tissue lacking AMPA subunit GluA1, which prevents confounding potentiation PSD-95. modifies conformation NMDAR C-terminal domain (CTD) and its interaction with protein phosphatase 1 (PP1), producing weakening. Higher endogenous...
We addressed the hypothesis that intraplantar botulinum toxin B (rimabotulinumtoxin B: BoNT-B) has an early local effect upon peripheral afferent terminal releasing function and, over time, will be transported to central terminals of primary afferent. Once in it cleave synaptic protein, block spinal transmitter release, and thereby prevent nociceptive excitation behavior. In mice, C57Bl/6 males, BoNT-B (1 U) given unilaterally into hind paw had no survival or motor function, but...
Spontaneously occurring miniature excitatory postsynaptic currents (mEPSCs) are fundamental electrophysiological events produced by quantal vesicular transmitter release at synapses. Their analysis can provide important information regarding pre- and function. However, the small signal relative to recording noise requires expertise considerable time for their identification. Furthermore, many mEPSCs smaller than ~8 pA not well resolved (e.g., those distant synapses or with few receptor...
Recently researchers have proposed using deep learning-based systems for malware detection. Unfortunately, all learning classification are vulnerable to adversarial attacks, or where miscreants can avoid detection by the algorithm with very few perturbations of input data. Previous work has studied attacks against static analysis-based classifiers which only classify content unknown file without execution. However, since majority is either packed encrypted, based on analysis often fails...
Recently researchers have proposed using deep learning-based systems for malware detection. Unfortunately, all learning classification are vulnerable to adversarial attacks. Previous work has studied attacks against static analysis-based classifiers which only classify the content of unknown file without execution. However, since majority is either packed or encrypted, based on analysis often fails detect these types files. To overcome this limitation, anti-malware companies typically...
Pruriceptive itch originates following activation of peripheral sensory nerve terminals when pruritogens come in contact with the skin. The ability botulinum neurotoxins (BoNTs) to attenuate transmitter release from afferent provides a rationale for studying its effect on pruritus. This study investigated effects BoNT/A1 and BoNT/B1 mast cell dependent (Compound 48/80:48/80) independent (Chloroquine:CQ) scratching. C57Bl/6 male mice received intradermal injection 1.5 U BoNT/A1, or saline 2,...
Mononeuropathies (MNs: nerve ligation) and polyneuropathies (PNs: cisplatin) produce unilateral bilateral tactile allodynia, respectively. We examined the effects of intraplantar (IPLT) intrathecal (IT) botulinum toxin B (BoNT-B) on this allodynia.Mice (male c57Bl/6) were prepared with an L5 ligation. Others received cisplatin (IP 2.3 mg/kg/d, every other day for 6 injections). Saline BoNT-B administered through IPLT or IT route. mechanical allodynia (von Frey hairs) before at intervals...
Abstract Increasing evidence suggests that botulinum neurotoxins (Bo NT s) delivered into the skin and muscle in certain human animal pain states may exert antinociceptive efficacy though their uptake transport to central afferent terminals. Cleavage of soluble N‐methylaleimide‐sensitive attachment protein receptor by Bo s can impede vesicular mediated neurotransmitter release as well transport/insertion channel/receptor subunits plasma membranes, an effect reduce activity‐evoked...
OBJECTIVE: To characterize effects of intrathecal (IT) and intraplantar (iplt) Botulinum Toxin B (BoNTB) on allodynia arising from a mono (MN) polyneuropathy (PN). BACKGROUND: Intrathecal botulinum toxin yields potent analgesia in murine mononeuropathy model. Recent work has suggested possible peripheral action the BoNTs. We extended our initial examining IT (IPLT) BoNTB MN poly neuropathy (PN) mice. DESIGN/METHODS: An was prepared by ligating L5 spinal nerve root. A PN made injecting...