A5008244627- Wnt/β-catenin signaling in development and cancer
- Advanced Optical Sensing Technologies
- Liver physiology and pathology
- Optical Coherence Tomography Applications
- Random lasers and scattering media
- Near-Field Optical Microscopy
- Cancer-related gene regulation
- Neural Networks and Reservoir Computing
- Advanced Fluorescence Microscopy Techniques
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Integrated Circuits and Semiconductor Failure Analysis
- Agricultural and Food Production Studies
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Kruppel-like factors research
- Food Safety and Hygiene
- FOXO transcription factor regulation
- Public Health and Environmental Issues
- Digital Holography and Microscopy
University of Bristol
2021-2023
Bristol Robotics Laboratory
2021-2022
University of Cienfuegos
2016
Inserm
2008-2013
Institut Cochin
2008-2013
Université Paris Cité
2008-2013
Centre National de la Recherche Scientifique
2008-2013
β-catenin signaling can be both a physiological and oncogenic pathway in the liver. It controls compartmentalized gene expression, allowing liver to ensure its essential metabolic function. is activated by mutations 20%-40% of hepatocellular carcinomas (HCCs) with specific features. We decipher molecular determinants β-catenin-dependent zonal transcription using mice β-catenin-activated or -inactivated hepatocytes, characterizing vivo their chromatin occupancy T-cell factor (Tcf)−4...
Traditional remote sensing applications are often based on pulsed laser illumination with a narrow linewidth and characteristic repetition rate, which not conducive to covert operation. Whatever methods employed for sensing, key requirement is the probe light be indistinguishable from background illumination. We present method perform single-pixel imaging that suppresses effect of hence improves signal-to-noise ratio by using correlated photon-pairs produced via spontaneous parametric down...
Using two entangled photons of different colors in a Hong-Ou-Mandel interference scheme, the authors show that they can precisely measure thickness semitransparent sample. The depth sensitivity is adjustable and method resilient against fluctuations commonly encountered biological samples.
Glycerol is a clinical biomarker of lipolysis that mainly produced by adipose tissues. Blood glycerol content increases in pathological conditions such as metabolic and cardiovascular diseases or cancer cachexia, but also response to energetic stress physical exercise. Accurate monitoring therefore important range healthcare contexts. However, current methods available for the quantification are expensive, time-consuming, require extraction plasma from blood, which blood then extrapolated....
Hong-Ou-Mandel (HOM) interference results in a modified probability of bunching events when indistinguishable photons with relative timing offset interact at beamsplitter. Lyons et al. recently achieved attosecond precision time delay measurement by applying classical Fisher information analysis to HOM [1]. More an increase the has been shown detuning central wavelengths signal and idler from entangled two-colour photon pair source applied temperature drift detection for optical fibres [2]....
We present a method of using high-flux entangled photon-pair source to improve the signal-to-noise ratio single-pixel imaging system. Sensing with single-photon counting detectors will often suffer from measurement noise due any background light levels. Using single detector enables high efficiency detection and when paired variable transmission mask full images be captured. The heralding photon acts as temporal reference, allowing signal photons distinguished noise. This is key...
We demonstrate the use of Hong-Ou-Mandel interference to resolve < 10 µm scale depth-features a semi-transparent sample and incorporate confocal imaging for 3D microscopy using photons from wavelength-entangled pair photon source.
The quantum interference of two wavelength-entangled photons overlapping at a beamsplitter results in an oscillating pattern. frequency the beat note is dependent on wavelength separation entangled but robust to scale perturbations that can limit practicality standard interferometry. Here we use two-colour entanglement interferometry evaluate variation thickness semi-transparent sample combination with two-dimensional raster scanning. axial precision and dynamic range microscope are actively...
Abstract Traditional remote sensing applications are often based on pulsed laser illumination with a narrow linewidth and characteristic repetition rate, which not conducive to covert operation. Whatever methods employed for sensing, key requirement is the probe light be indistinguishable from background illumination. We present method perform single-pixel imaging that suppresses effect of hence improves signal-to-noise ratio by using correlated photon-pairs produced via spontaneous...