Abstract Diabetic ulcer is the most common kind of chronic wound worldwide. Though great efforts have been devoted, diabetic still remains as a challenge that requires constant monitoring and management. In this work, multifunctional zwitterionic hydrogel developed to simultaneously detect two fluctuant parameters, pH glucose level, monitor status. A indicator dye (phenol red) sensing enzymes, oxidase (GOx) horseradish peroxidase (HRP), are encapsulated in anti‐biofouling biocompatible...

Abstract Conductive hydrogels have emerged as fascinating materials applied in flexible electronics because of their integrated conductivity and mechanical flexibility. However, the large amounts water conductive inevitably freeze at subzero temperature, causing a reduction ionic transport ability elasticity. Herein, bioinspired antifreezing agents—zwitterionic osmolytes (e.g., betaine, proline) are first proposed to prevent ammonium chloride‐containing Ca‐alginate/polyacrylamide from...

PDMS-based materials have been extensively studied in oil-water separation. However, their successful application is commonly limited by low efficiency, vulnerability to acid/alkali, complex processing procedures, incapability for emulsion separation, etc. Here, a highly durable and robust separation material developed coating copolymers on cotton textiles with facile sol-gel approach. Solely driven gravity, this new not only can enable effective of mixture flux as high ∼7500 L m-2 h-1 but...

Conductive hydrogels have been extensively used in wearable skin sensors owing to their outstanding flexibility, tissuelike compliance, and biocompatibility. However, the dehydration embrittlement of can result sensitivity loss or even invalidation, restraining applications external environments, especially at low temperatures arid environments. Herein, an environment-resistant organohydrogel is developed for multifunctional sensors. A double-network based on hyaluronic acid poly(acrylic...

Cryoprotectants (CPAs) are critical to successful cryopreservation because they can protect cells from cryoinjuries. Because of the limitations current CPAs, especially toxicity, search for new effective CPAs is attracting increasing attention. In this work, we reported that natural biocompatible osmoprotectants, which could osmotic injury in various biological systems, might also be ideal candidates CPAs. Three representative osmoprotectants (proline, glycine, and taurine) were tested...

Purpose The purpose of this paper is to provide reference for researchers by reviewing the research advances and trend agricultural product price forecasting methods in recent years. Design/methodology/approach This reviews main their application prices, summarizes examples common methods, prospects future directions. Findings 1) It use hybrid models predict products prices research; 2) prediction model based on influencing factors should be further expanded 3) performance evaluated DS...

Abstract Cell cryopreservation has evolved as an important technology required for supporting various cell-based applications, such stem cell therapy, tissue engineering, and assisted reproduction. Recent times have witnessed increase in the clinical demand of these requiring urgent improvements cryopreservation. However, suffers from issues low efficiency cryoprotectant (CPA) toxicity. Application advanced biotechnology tools can significantly improve post-thaw survival reduce or even...

Cryopreservation of red blood cells (RBCs) is fundamentally important to modern transfusion medicine. Currently, organic solvent glycerol utilized as the state-of-the-art cryoprotectant (CPA) for RBC cryopreservation. However, must be removed before avoid intravascular hemolysis via a time-consuming deglycerolization process with specialized equipment (e.g., ACP 215), thus limiting clinical use frozen RBCs. Herein, we report novel biocompatible CPA formulations combining betaine membrane...

The mouse incisor is a key model system for understanding the regulatory mechanisms governing dental stem cells (SCs). However, effects of sex, age and strain on morphology epithelial SC function remain unclear. We used micro-computed tomography histology to analyze apical region in males females, two groups, commonly strains. Cell kinetics, enamel density, volume were assessed determine their impact behavior properties. No differences found cell kinetics or properties between male female...

A metal–organic framework (MOF)-based antibiofouling hemoadsorbent (PCB-MIL101) was developed through a facile encapsulation of MIL-101(Cr) in zwitterionic poly carboxybetaine (PCB) hydrogel. PCB-MIL101 possessed strong mechanical strength and superior hemocompatibility, ensuring its safety hemoperfusion applications. In addition, it showed efficient effective adsorption toward bilirubin (BR), maximum capacity ∼583 mg g–1. Moreover, due to the protection PCB hydrogel, ability resist protein...

Freeze-tolerant hydrogels can regulate the freezing behavior of water inside them at subzero temperatures, thus maintaining their exceptional properties (e.g., intelligent responsiveness and liquid transporting) extending applications under cold conditions. Herein, a series aggregation-induced emission (AIE)-active freeze-tolerant are developed, which enable information encryption decryption temperatures. The possess varied temperatures (Tf) depending on betaine concentration. Above/below...

A bifunctional antifouling and endothelial cell selective coating, based on a zwitterionic hydrogel the REDV peptide, can promote re-endothelialization achieve multi-resistance of proteins, bacteria, blood cells smooth muscle cells.

The development of effective antifreeze peptides to control ice growth has attracted a significant amount attention yet still remains great challenge. Here, we propose novel design method based on an in-depth investigation repetitive motifs in various ice-binding proteins (IBPs) with evolution analysis. In this way, several notable activity were developed. particular, designed peptide named AVD exhibits ideal recrystallization inhibition (IRI), solubility, and biocompatibility, making it...

Cartilage tissue engineering highly relies on the ability to store and transport chondrocytes in order be clinically successful. Cryopreservation is a most reliable technology for chondrocyte storage, but it suffers from intrinsic toxicity of current state-of-the-art cryoprotectant, dimethyl sulfoxide (DMSO). In this work, we used first fully zwitterionic compound-based approach effective cryopreservation. A molecule combined with polymers could balance intra/extracellular osmotic stress...

Currently, the state-of-the-art cryoprotectants for cell cryopreservation have bottleneck problems (such as cytotoxicity), which place enormous logistical limitations to development of regenerative medicine. In this work, a first alginate polymer-based approach human chondrocyte is reported. Combined with zwitterionic betaine, natural osmoprotectant offer intracellular protection, can achieve ∼90% efficiency. Because biocompatibility polymer and easily retrieve post-thaw cells without...

Hypothermic preservation at a refrigerated temperature allows feasible and flexible storage of living cells, is great importance for the widespread use cell-based applications, such as cell diagnostics therapy. The University Wisconsin (UW) cold solution one current state-of-the-art protectants hypothermic preservation. However, even by using UW solution, effective time under conditions still no more than 1 or 2 days, which restraints larger geographic cell-sharing regions. Herein, we...

Efficient cryopreservation of stem cells is crucial to fabricating off-the-shelf cell products for tissue engineering and regeneration medicine. However, it remains challenging due utilization toxic cryoprotectants reducing ice-related cryodamages during freeze-thaw cycle, stringent post-thaw washing process, further integration with scaffolds form constructs downstream applications. Herein, a novel platform based on an antifreezing polyvinylpyrrolidone/gellan gum/gelatin (PGG) scaffold...

Perforator stroke is one of the most common complications elective intracranial angioplasty and/or stenting, particularly in basilar artery. Factors associated with risk post-procedural perforator remain unexplored. We investigated factors affecting after artery stenting.Consecutive patients undergoing stenting due to symptomatic atherosclerotic stenosis were retrospectively included this single-center study. Analyzed variables including demographic data, atherosclerosis, symptoms,...