A5081100480- Pancreatic function and diabetes
- Diabetes Management and Research
- Diabetes and associated disorders
- Plant Water Relations and Carbon Dynamics
- High Altitude and Hypoxia
- Neuroscience and Neuropharmacology Research
- Fire effects on ecosystems
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Mitochondrial Function and Pathology
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Eicosanoids and Hypertension Pharmacology
- Cryospheric studies and observations
- Ion Transport and Channel Regulation
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Cardiac electrophysiology and arrhythmias
- Cancer Risks and Factors
- Genetic Neurodegenerative Diseases
- Sympathectomy and Hyperhidrosis Treatments
- Precipitation Measurement and Analysis
- Neuroendocrine Tumor Research Advances
- Inflammasome and immune disorders
- MicroRNA in disease regulation
Zhejiang University
2025
First Affiliated Hospital Zhejiang University
2025
Air Force Medical University
2000-2024
Air Force Engineering University
2023-2024
University of Maryland, Baltimore
2003-2012
Huazhong University of Science and Technology
2011
Tongji Hospital
2011
University of Maryland Medical Center
2003-2004
Universität Ulm
1996
Graduate Hospital
1995
Glutamate receptor (GluR) channels are responsible for a number of fundamental properties the mammalian central nervous system, including nearly all excitatory synaptic transmission, plasticity, and excitotoxin-mediated neuronal death. Although many human rodent neuroblast cell lines available, none has been directly shown to express GluR channels. We report here that cells from teratocarcinoma line NT2 induced by retinoic acid N-methyl-D-aspartate (NMDA) non-NMDA concomitant with their...
Certain anesthetics exhibit neurotoxicity in the brains of immature but not mature animals. γ-Aminobutyric acid (GABA), primary inhibitory neurotransmitter adult brain, is excitatory on neurons via its action at GABAA receptor, depolarizing membrane potential and inducing a cytosolic Ca2+ increase ([Ca2+]i), because reversed transmembrane chloride gradient. Recent experimental data from several rodent studies have demonstrated that exposure to isoflurane during an initial phase causes...
Lymphatics are important for their conduit functions of transporting antigen, immune cells, and inflammatory mediators to draining lymph nodes the general circulation. Lymphangiogenesis is involved in many pathologic processes; however, roles lymphatic responses transplantation have not been thoroughly investigated.Mice were made diabetic by a single high dose streptozotocin then received islet allografts. Animals treated with three different inhibitors. FTY720, an analog sphingosine...
The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. present study was conducted to explore the possible mechanisms by which GPR55 regulates and evaluate effectiveness of O-1602 treatment anxiety-like symptoms. Mice were exposed two types acute stressors: restraint forced swimming. Anxiety behavior evaluated using elevated plus maze open field test. We found that alleviated acutely stressed mice. used lentiviral shRNA...
BACKGROUND Serial myocardial perfusion imaging with 99mTc-sestamibi (MIBI) was used to evaluate infarct risk area and salvage after thrombolysis. The purpose of this investigation determine whether changes in MIBI defect size observed reperfusion may result part from distortion regional global left ventricular geometry. METHODS AND RESULTS Twenty-five open-chest dogs were subjected either 15 minutes (groups 1A 1B) or 3 hours (group 2) anterior descending coronary artery occlusion followed by...
Fragile X syndrome (FXS) is a form of inherited mental retardation that results from the absence fragile protein (FMRP), product Fmr1 gene. Numerous studies have shown FMRP expression in astrocytes important development FXS. Although affect neuronal dendrite knockout (KO) mice, factors released by are still unclear. We cultured wild type (WT) cortical neurons astrocyte-conditioned medium (ACM) WT or KO mice. Immunocytochemistry and Western blotting were performed to detect dendritic growth...
Hypoxia impairs blood-brain barrier (BBB) structure and function, causing pathophysiological changes in the context of stroke high-altitude brain edema. Brain microvascular endothelial cells (BMECs) are major structural functional elements BBB, their exact role hypoxia remains unknown. Here, we first deciphered molecular events that occur BMECs under 24 h by whole-transcriptome sequencing assay. We found inhibited BMEC cell cycle progression proliferation downregulated minichromosome...
In addition to debilitating sensory and motor deficits, patients with spinal cord injury (SCI) may experience chronic hyperpathic pain (SCI-pain). Recent studies have revealed that translocator protein (TSPO) is involved in repairing neural cells as well reducing anxiety depression. However, the role of TSPO SCI-pain pain-induced depression remains unknown. The present study aimed determine effects a new ligand, ZBD-2, on consequent depressive-like behaviors mice. Treatment ZBD-2 at either...
High-altitude pulmonary hypertension (HAPH) is a severe and progressive disease that can lead to right heart failure. Intermittent short-duration reoxygenation at high altitude effective in alleviating HAPH; however, the underlying mechanisms are unclear. In present study, simulated 5,000-m hypoxia rat model hypoxic cultured artery smooth muscle cells (PASMCs) were used evaluate effect of intermittent reoxygenation. The results showed 3-h/per day (I3) effectively attenuated chronic...
High-altitude pulmonary hypertension (HAPH) is a severe and progressive disease caused by chronic hypoxia subsequent vascular remodeling. No cure currently available owing to an incomplete understanding about It believed that hypoxia-induced diseases can be prevented treating hypoxia. Thus, this study aimed determine whether daily short-duration reoxygenation at sea level attenuates under high-altitude To end, simulated 5000-m rat model hypoxic cultured human artery smooth muscle cells were...
Islet transplantation has great potential for curing type 1 diabetes; however, long-term islet survival using conventional immunosuppression remains elusive. We present a novel strategy inducing long-lasting graft in diabetic NOD mice the absence of posttransplant by initial treatment with antilymphocyte serum (ALS) followed coadministration donor pancreatic lymph node cells (PLNCs). When treated ALS/PLNC, become normoglycemic and tolerated minor antigen-disparate grafts >100 days syngeneic...
The effects of activating the beta-adrenoceptor pathway on calcium current (ICa) in rabbit portal vein (PV) were studied myocytes freshly isolated by collagenase and elastase treatment. ICa was measured at room temperature (20 degrees C) using whole cell, voltage-clamp methods from a holding potential -60 mV cells dialyzed with pipette solution containing (mM) 100 CsCl, 20 tetraethylammonium chloride, 5 NaCl, MgATP, N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES), 10...
Abstract High altitude pulmonary hypertension (HAPH) is a chronic progressive disease caused by the reconstruction of distal arterioles hypoxia. Due to limited effect current protective measures for treating HAPH, we propose use intermittent short-duration reoxygenation and prove its effectiveness in protecting against HAPH an animal model. However, mechanism relieving still needs be further clarified. Previous studies have shown that alveolar macrophages inflammatory response induced NLRP3...
Transplantation: July 27, 2008 - Volume 86 Issue 2S p 450 doi: 10.1097/01.tp.0000331475.78718.ed