A5100460530- Spaceflight effects on biology
- High Altitude and Hypoxia
- Anesthesia and Neurotoxicity Research
- Nitric Oxide and Endothelin Effects
- Advanced Photocatalysis Techniques
- Birth, Development, and Health
- Advanced biosensing and bioanalysis techniques
- Eicosanoids and Hypertension Pharmacology
- Sleep and Work-Related Fatigue
- Mitochondrial Function and Pathology
- Electrocatalysts for Energy Conversion
- Adipose Tissue and Metabolism
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Electrochemical Analysis and Applications
- Advanced Nanomaterials in Catalysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Pregnancy and preeclampsia studies
- interferon and immune responses
- RNA modifications and cancer
- Human-Automation Interaction and Safety
Air Force Medical University
2014-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Seventh People's Hospital of Shanghai
2023-2025
National Synchrotron Radiation Laboratory
2025
University of Science and Technology of China
2025
Soochow University
2022-2025
Henan Normal University
2024
National Institutes of Health
2023-2024
Guangdong Pharmaceutical University
2024
Jiangsu University
2022-2024
Trypanosoma cruzi, the agent of Chagas disease, can be subdivided into six discrete typing units (DTUs), TcI, TcIIa, TcIIb, TcIIc, TcIId or TcIIe, each having distinct epidemiologically important features. Dozens genetic markers are available to determine DTU which a T. cruzi isolate belongs, but there is no consensus on should used. We selected five assays: three polymerase chain reaction (PCR)-restriction fragment length polymorphisms based single nucleotide (SNPs) in HSP60, Histone H1,...
A smart coating integrating functions of corrosion inhibition, self-healing, and corrosion-sensing was developed based on a polyaniline (PANI) microsphere-loading sensing probe (8-hydroxyquinone, 8-HQ). The PANI microsphere prepared in facile one-pot process via the combination photopolymerization an emulsion template. 8-HQ-loaded achieved three synergetic effects simultaneously: sensing, photothermal self-healing abilities. Benefiting from inhibition effect PANI, with exhibited...
Abstract The mechanisms that drive placental dysfunction in pregnancies complicated by hypoxia and fetal growth restriction remain poorly understood. Changes to mitochondrial respiration contribute cellular conditions of have been implicated the pathoaetiology pregnancy complications, such as pre‐eclampsia. We used bespoke isobaric hypoxic chambers a combination functional, molecular imaging techniques study metabolism dynamics sheep undergoing pregnancy. show triggers shift capacity away...
The purpose of this study was to investigate the anti-fatigue effect natural Lycium barbarum polysaccharide (LBP) during exercise, develop a functional effervescent tablet by applying LBP practical products, and help patients who have difficulty swallowing conventional tablets or capsules. extracted with water, DEAE-52 cellulose used for purification. chemical structure monosaccharide composition Fourier transform infrared spectroscopy (FI-IR) ion chromatography (IC). (LBPT) were prepared...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by various disabling symptoms including exercise intolerance and diagnosed in the absence of a specific cause, making its clinical management challenging. A better understanding molecular mechanism underlying this apparent bioenergetic deficiency state may reveal insights for developing targeted treatment strategies. We report that overexpression
This study aimed to investigate the effects of sleep deprivation on postural control, subjective fatigue assessment and psychomotor performance, assess efficiency an objective posturographic test as indicator mental fatigue. Postural sway using static posturography (Romberg's test), (Stanford Sleepiness Scale) performance (Sternberg dual-task test) were assessed in 12 subjects before after 24 h sustained wakefulness. After wakefulness, Romberg parameters circumference area rectangle with...
Non-suicidal self-injury (NSSI) is a risk factor for suicide. This study aimed to investigate the prevalence of NSSI and professional psychological help-seeking status influencing factors among left-behind children (LBC) in China.We implemented population-based cross-sectional participants aged 10-18 years. Sociodemographic characteristics, NSSI, coping style were measured by self-reported questionnaires. A total 16,866 valid questionnaires collected, including 6096 LBC. Binary logistic...
Gestational hypoxia adversely affects uterine artery function, increasing complications. However, an effective therapy remains unidentified. Here, we show in rodent arteries that hypoxic pregnancy promotes hypertrophic remodelling, increases constrictor reactivity via protein kinase C signalling, and triggers compensatory dilatation nitric oxide-dependent mechanisms stimulation of large conductance Ca
Objective To investigate the effects of light fasting diet therapy, including flaxseed powder supplementation, on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome (PCOS) combined infertility.
Kawasaki disease (KD) is a medium-vessel vasculitis predominantly affecting children under 5 years of age and may involve the coronary arteries. A mouse KD model was induced by Candida albicans cell wall extracts (CAWS), cardiac tissues were analyzed through integrated lactylomic proteomic profiling. The lysine lactylation (Kla) results normalized to data. Elevated serum lactate dehydrogenase (LDH) levels observed in patients. Given lactate's role as substrate for Kla, this study...
Aqueous Zinc‐based batteries provide promising opportunities for next‐generation rechargeable batteries. Nevertheless, Zn anode encounters severe challenges, such as dendrite formation, surface corrosion, and hydrogen evolution reaction (HER). Here, we report a strategy to spontaneously construct boron‐fluoride dual‐atom regulated SEI (ZnBOF), which involves the formation of B‐compound coating through etching process followed by an in‐situ F substitution during initial electrochemical...
Recently, hypertrophy and increased myogenic tone of brain vessels have been observed in rats after simulated microgravity. It is expected that microgravity may also induce hyperreactivity vessels. To test this hypothesis, Sprague-Dawley were subjected to a 4-wk tail-suspended hindlimb unloading (TS) simulate the cardiovascular deconditioning effect After 4 wk, vasoreactivity isolated basilar arterial rings from TS both receptor- non-receptor-mediated vasoconstrictors, such as KCl, arginine...
Previous studies have demonstrated activation of the local renin-angiotensin system in hindlimb unweighting (HU) rat vasculature. The present study intended to identify effects blockade angiotensin II (ANG II) type 1 (AT(1)) receptors with losartan on vascular reactivity, nitric oxide synthase (NOS) expression, and superoxide anion (O(2)(*-)) levels 3-wk HU cerebral carotid arteries. Three weeks later, vasoconstriction, vasodilatation, endothelial NOS (eNOS) inducible (iNOS) protein, as well...
This study was designed to test the hypothesis that a 28-day tail suspension (SUS) could induce hypertrophy and enhanced myogenic vasoconstrictor reactivity in middle cerebral arteries (MCAs), whereas atrophy decreased responses mesenteric third-order arterioles (MSAs). Also, addition functional enhancement MCAs, structural changes both kinds of decrement MSAs all be prevented by intervention daily 1-h dorsoventral (-G(x)) gravitation restoring standing posture. To this hypothesis, vessel...
Driven by the essential need of a green, safe, and low-cost approach to producing H2O2, highly valuable multifunctional chemical, artificial photosynthesis emerges as promising avenue. However, current catalyst systems remain challenging, due high-density sunlight, poor selectivity/activity, or/and unfavorable thermodynamics. Here, we reported that an indirect 2e- water oxidation reaction (WOR) in photocatalytic H2O2 production was unusually activated C5N2 with piezoelectric effects. Under...
The endosymbiotic theory posits that ancient eukaryotic cells engulfed O2-consuming prokaryotes, which protected them against O2 toxicity. Previous studies have shown lacking cytochrome c oxidase (COX), required for respiration, increased DNA damage and reduced proliferation, could be improved by reducing exposure. With recently developed fluorescence lifetime microscopy–based probes demonstrating the mitochondrion has lower [O2] than cytosol, we hypothesized perinuclear distribution of...
The aim of the present work was to investigate alterations in nitric oxide synthase (NOS) expression and nitrate nitrite (NOx) content different arteries from simulated microgravity rats. Male Wistar rats were randomly assigned either a control group or group. For simulating microgravity, animals subjected hindlimb unweighting (HU) for 20 days. Different arterial tissues removed determination NOS NOx. Western blotting used measure endothelial (eNOS) inducible (iNOS) protein content. Total...
Cerebral arterial remodeling is one of the critical factors in occurrence postspaceflight orthostatic intolerance. We hypothesize that large-conductance calcium-activated K(+) (BK(Ca)) channels vascular smooth muscle cells (VSMCs) may play an important role regulating cerebrovascular adaptation during microgravity exposure. The aim this work was to investigate whether activation BK(Ca) involved regulation apoptotic cerebral arteries simulated rats. In animal studies, Sprague-Dawley rats were...
Background The differential adaptations of cerebrovasculature and small mesenteric arteries could be one critical factors in postspaceflight orthostatic intolerance, but the cellular mechanisms remain unknown. We hypothesize that there is a regulation intracellular Ca2+ determined by alterations functions plasma membrane CaL channels ryanodine-sensitive releases from sarcoplasmic reticulum (SR) cerebral vascular smooth muscle cells (VSMCs) simulated microgravity rats, respectively....
Genome wide association studies (GWAS) already have identified tens of susceptible loci for nonsyndromic cleft lip with or without palate (NSCL/P). However, whether these associated only (NSCPO) remains unknown.In this study, we replicated 38 SNPs (Single nucleotide polymorphisms) which has the most significant p values in published GWASs, genotyping by using SNPscan among 144 NSCPO trios from Western Han Chinese. We performed transmission disequilibrium test (TDT) on individual and...