A5027208839- Cancer therapeutics and mechanisms
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- Medical Imaging Techniques and Applications
- Cancer Treatment and Pharmacology
- DNA Repair Mechanisms
- S100 Proteins and Annexins
- Glycosylation and Glycoproteins Research
- Economic and Environmental Valuation
- Healthcare Systems and Reforms
- Advanced Neuroimaging Techniques and Applications
- Lysosomal Storage Disorders Research
- Carbohydrate Chemistry and Synthesis
- Global Health Care Issues
- Diet and metabolism studies
Southwest Petroleum University
2020
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2020
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark several neurodegenerative diseases including Alzheimer's disease. In vivo detection NFTs using PET imaging represents a unique opportunity to develop pharmacodynamic tool accelerate discovery new disease modifying therapeutics targeting pathology. Herein, we present 6-(fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine, 6 ([(18)F]-MK-6240), novel tracer for...
Inhibition of O-GlcNAcase (OGA) has emerged as a promising therapeutic approach to treat tau pathology in neurodegenerative diseases such Alzheimer's disease and progressive supranuclear palsy. Beginning with carbohydrate-based lead molecules, we pursued an optimization strategy reducing polar surface area align the desired drug-like properties potency, selectivity, high central nervous system (CNS) exposure, metabolic stability, favorable pharmacokinetics, robust vivo pharmacodynamic...
Abstract A majority of patients with cancer receive radiotherapy as part their treatment regimens whether using external beam therapy or locally-delivered radioisotopes. While often effective, some tumors are inadequately controlled radiation and has significant short-term long-term toxicities for survivors. Insights into molecular mechanisms involved in cellular responses to DNA breaks introduced by other therapies have been gained recent years approaches manipulate these enhance tumor cell...
Comprehensive investigation on understanding geographical inequalities of healthcare resources and their influencing factors in China remains scarce. This study aimed to explore both spatial temporal heterogeneous impacts various socioeconomic environmental resource at a fine-scale administrative county level. We collected data county-level hospital beds per ten thousand people represent resources, as well 32 candidate covariates southwest from 2002 2011. innovatively employed cutting-edge...
Abstract A majority of cancer patients receive radiation therapy (RT) as part their treatment regimens, whether using external beam or locally-delivered radioisotopes. While often effective, RT may not be efficacious for some tumors while exerting significant short-term and long-term toxicities. Thus, enhancing therapeutic effectiveness remains an important goal. ATM (ataxia-telangiectasia, mutated) DNA-PKcs (deoxyribonucleic acid [DNA]-dependent protein kinase, catalytic subunit) are...
<p>Plasma concentrations</p>
<p>MAGeCK-Analysis</p>
<p>FaDu clonogenic survival treated with XRD-0394</p>
<p>XRD-0394 radiosensitization compared with ATRi</p>
<p>MAGeCK-Analysis</p>
<p>MCF7 clonogenic survival treated with XRD-0394</p>
<p>Results of Kinase Panel Screen-1</p>
<p>Potentiation of SN38</p>
<p>MDA-MB-231 clonogenic survival treated with XRD-0394</p>
<p>Western blots</p>
<p>Plots of CTG assays</p>
<p>Results of Kinase Panel Screen-2</p>
<p>clonogenic survival colonies</p>
<p>FaDu clonogenic survival treated with XRD-0394</p>
<p>in vivo efficacy with radiation</p>
<p>Clonogenic survival treated with ATMi, DNA-PKi, the combination and XRD-0394</p>
<p>Kinase Assays and synthesis of XRD-0394</p>
<p>Plasma concentrations</p>
<p>Clonogenic survival treated with ATMi and DNA-PKi combination</p>
<p>toxicity and KEAP1 cell lines</p>