A5074622455- Cancer therapeutics and mechanisms
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Estrogen and related hormone effects
- Pharmacogenetics and Drug Metabolism
- Vitamin D Research Studies
- Neonatal Respiratory Health Research
- Alkaline Phosphatase Research Studies
- DNA Repair Mechanisms
- Glutathione Transferases and Polymorphisms
- Bone health and osteoporosis research
Bayer (United States)
1999
Washington University in St. Louis
1990
Karolinska Institutet
1987
We report here that the bacterial lipopolysaccharide endotoxin induces human blood monocytes in a time- and dose-dependent manner to release prodigious amounts of prostaglandins with thromboxane A2, major metabolite formed. Cells responded as little 1 ng/ml prostaglandin E2 A2 maximal stimulation at 10 micrograms/ml. Lipopolysaccharide was found induce increased activity cyclooxygenase enzyme without affecting activities phospholipase synthase or formation 5-lipoxygenase products (e.g....
Abstract A majority of patients with cancer receive radiotherapy as part their treatment regimens whether using external beam therapy or locally-delivered radioisotopes. While often effective, some tumors are inadequately controlled radiation and has significant short-term long-term toxicities for survivors. Insights into molecular mechanisms involved in cellular responses to DNA breaks introduced by other therapies have been gained recent years approaches manipulate these enhance tumor cell...
A cDNA clone corresponding to leukotriene A4 hydrolase was isolated from a human lung lambda gt11 expression library by immunoscreening with polyclonal antiserum. Several additional clones and placenta g11 libraries were obtained plaque hybridization the 32P-labeled clone. One of these has an insert 1910 base pairs that contains complete protein-coding region. From deduced primary structure, is 610 amino protein calculated molecular weight 69,140. No apparent homologies microsomal epoxide...
Abstract A majority of cancer patients receive radiation therapy (RT) as part their treatment regimens, whether using external beam or locally-delivered radioisotopes. While often effective, RT may not be efficacious for some tumors while exerting significant short-term and long-term toxicities. Thus, enhancing therapeutic effectiveness remains an important goal. ATM (ataxia-telangiectasia, mutated) DNA-PKcs (deoxyribonucleic acid [DNA]-dependent protein kinase, catalytic subunit) are...
<p>Plasma concentrations</p>
<p>MAGeCK-Analysis</p>
<p>FaDu clonogenic survival treated with XRD-0394</p>
<p>XRD-0394 radiosensitization compared with ATRi</p>
<p>MAGeCK-Analysis</p>
<p>MCF7 clonogenic survival treated with XRD-0394</p>
<p>Results of Kinase Panel Screen-1</p>
<p>Potentiation of SN38</p>
<p>MDA-MB-231 clonogenic survival treated with XRD-0394</p>
<p>Western blots</p>
<p>Plots of CTG assays</p>
<p>Results of Kinase Panel Screen-2</p>
<p>clonogenic survival colonies</p>
<p>FaDu clonogenic survival treated with XRD-0394</p>
<p>in vivo efficacy with radiation</p>
<p>Clonogenic survival treated with ATMi, DNA-PKi, the combination and XRD-0394</p>
<p>Kinase Assays and synthesis of XRD-0394</p>
<p>Plasma concentrations</p>
<p>Clonogenic survival treated with ATMi and DNA-PKi combination</p>