A5083013604- MicroRNA in disease regulation
- Redox biology and oxidative stress
- DNA Repair Mechanisms
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Genomics, phytochemicals, and oxidative stress
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Protein Tyrosine Phosphatases
- Heat shock proteins research
- RNA regulation and disease
- Glutathione Transferases and Polymorphisms
- Circular RNAs in diseases
- Connexins and lens biology
- Endoplasmic Reticulum Stress and Disease
- Retinal Development and Disorders
- Virus-based gene therapy research
- Sulfur Compounds in Biology
- Epigenetics and DNA Methylation
- Carcinogens and Genotoxicity Assessment
Indiana University Bloomington
2009
Kyoto University
2005-2007
Recently Welch et al . reported that microRNA (miRNA)‐34a functions as a potential tumor suppressor in neuroblastoma cells ( Oncogene 26: 5017–22, 2007). Here, we conversely show miRNA‐34a supports cell proliferation rat oxidative stress‐induced renal carcinogenesis and is overexpressed various types of human cancers. While searching for genetically unstable chromosomal areas carcinogenesis, found the miRNA‐34 family reciprocally with frequent allelic loss. By situ hybridization reverse...
Mitochondrial Thioredoxin-Interacting Protein (TXNIP) has emerged as a pivotal regulator in cellular redox homeostasis, influencing spectrum of physiological and pathological processes. Initially identified for its role modulating thioredoxin (TRX) activity, recent discoveries highlight TXNIP’s mitochondrial localization, significantly broadening functional landscape. This review elucidates the discovery TXNIP, regulatory mechanisms, implications across various diseases. The groundbreaking...
An iron chelate, ferric nitrilotriacetate (Fe‐NTA), induces oxidative renal proximal tubular damage that subsequently leads to a high incidence of cell carcinoma in rodents, presenting an intriguing model free radical‐induced carcinogenesis. In the present study, we used gpt delta transgenic mice, which allow efficient detection point mutations and deletions vivo, evaluate mutation spectra, association with formation 8‐oxoguanine acrolein‐modified adenine during first 3 weeks...
MicroRNAs (miRNAs) are endogenous ~22 nt RNAs. miRNAs traditionally considered primarily cytoplasmic molecules that regulate gene expression posttranscriptionally by targeting mRNAs for degradation or translational repression. In the canonical pathway of biogenesis, pri-miRNAs transcribed from DNA sequences inside cell nucleus. Pri-miRNAs then processed Drosha into pre-miRNAs and exported to cytoplasm via exportin 5 (XPO5)/RanGTP complex. Pre-miRNAs mature miRNA duplexes RNase III...
The discovery of microRNAs (miRNAs) has revolutionized our understanding gene regulation, particularly through their cell-type and context-specific functions. This perspective explores the gradual realization miRNA specificity, beginning with identification lin-4 in Caenorhabditis elegans progressing to tissue-specific miRNAs such as miR-122 liver miR-1 muscle. A central focus is miR-34a, one most studied miRNAs, which exemplifies importance cellular context function. miR-34a’s role tumor...
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia. Current therapeutic strategies primarily manage symptoms, leaving substantial unmet need for curative interventions. This review explores the potential of CRISPR-dCas9-mediated CpG island editing as promising approach T2DM. islands, DNA regions enriched in cytosine-guanine dinucleotides, play pivotal role gene regulation. Their methylation status significantly influences expression. By targeting...