A5060381862- Natural Compounds in Disease Treatment
- Plant Pathogens and Fungal Diseases
- Organic Chemistry Cycloaddition Reactions
- Fungal Plant Pathogen Control
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis and Biological Evaluation
- Natural product bioactivities and synthesis
Institute of Botany
2023-2024
Chinese Academy of Sciences
2023-2024
Tachysterol is an intermediate product in the synthesis of vitamin D 2 from ergosterol and 3 7-dehydrocholesterol under ultraviolet irradiation. Recent studies have shown that tachysterol also a crucial natural anti-tumor Chaxine C. Although there been numerous on other photoisomers ergosterol, research relatively limited. In addition, yield not high (57.0%), mechanism unclear. this study, method was developed for qualitative quantitative analysis tachysterol. Meanwhile, efficient process...
Phorbol esters and their derivatives, such as TPA, have been reported potential natural antitumor products, with some derivatives entering clinical research for leukemia treatment. In this study, 16 phorbol were synthesized from phorbol, anti-leukemia activity against Jurkat, HL-60, K562 tested. The results showed that several had activity, 5B demonstrating the strongest cytotoxic cell line (IC 50 = 0.24 ± 0.04 μM). Based on IC values, a structure-activity relationship was established. When...