C. Savopoulos

ORCID: 0009-0003-4181-7439
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About
Contact & Profiles
Research Areas
  • Lipoproteins and Cardiovascular Health
  • Blood Pressure and Hypertension Studies
  • Cerebrovascular and Carotid Artery Diseases
  • Hormonal Regulation and Hypertension
  • Peripheral Artery Disease Management
  • Nail Diseases and Treatments
  • Antibiotic Resistance in Bacteria
  • Platelet Disorders and Treatments
  • Connective Tissue Growth Factor Research
  • Genetic Syndromes and Imprinting
  • Pneumonia and Respiratory Infections
  • Acute Lymphoblastic Leukemia research
  • Fungal Biology and Applications
  • Inflammatory Biomarkers in Disease Prognosis
  • Protease and Inhibitor Mechanisms
  • Cardiovascular Health and Disease Prevention
  • Cardiac tumors and thrombi
  • Tumors and Oncological Cases
  • Parathyroid Disorders and Treatments
  • Blood properties and coagulation
  • Diabetes and associated disorders
  • Antifungal resistance and susceptibility
  • Folate and B Vitamins Research
  • Antibiotics Pharmacokinetics and Efficacy
  • Paraoxonase enzyme and polymorphisms

AHEPA University Hospital
2012-2025

Aristotle University of Thessaloniki
2010-2024

Imperial College London
2012-2016

The London College
2016

Gesundes Kinzigtal (Germany)
1983

<i>Introduction:</i> It has been shown recently that platelet indices like mean volume (MPV), size deviation width (PDW) and platelet-to-large-cell ratio (P-LCR) are helpful in the discrimination between hyperdestructive thrombocytopenia idiopathic thrombocytopenic purpura (ITP) hypoproductive (HT). The aim of study is to assess reliability these differentiation ITP from other thrombocytopenias. <i>Methods:</i> We recruited 134 patients (69 men, 65 women) who were...

10.1159/000135658 article EN Acta Haematologica 2008-01-01

Background and Objectives: Thyroid disease has been associated with autoimmune disorders. As systemic lupus erythematosus (SLE) is a diverse manifestations spanning across all organ systems, the relationship of SLE thyroid disorders needs investigation. In particular, attracted interest research community. The aim was to evaluate disease. Materials Methods: A cohort 45 consecutive patients mean age 47.97 years (range 21-79 years) age- sex-matched controls were prospectively studied over...

10.3390/medicina59111911 article EN cc-by Medicina 2023-10-29

What is known and objective Dasatinib a novel second-generation inhibitor of multiple tyrosine kinases, indicated for the treatment Philadelphia chromosome-positive (Ph+) chronic myeloid leukaemia (CML), acute lymphoblastic (ALL) lymphoid blast CML with resistance or intolerance to prior therapy. Although dasatinib potent, efficacious generally well-tolerated drug, patients are also subject various adverse effects. The most common pulmonary-related side effect pleural effusion (PE). Renal...

10.1111/jcpt.12107 article EN Journal of Clinical Pharmacy and Therapeutics 2013-11-05

Objective: Tissue inhibitor of metalloproteinase -1 (TIMP-1) has been identified in humans and its expression is regulated during development tissue remodeling. TIMP-1 overexpression a mouse model atherosclerosis showed lesion reduction. Interleukine-6 (IL-6) considered to be pro-inflammatory lipocytokine. The aim the present study was determine serum levels IL-6 investigate their potential correlation with hypertension, atherosclerotic markers albuminuria early stages type 2 diabetic...

10.1097/01.hjh.0000467492.91729.d5 article EN Journal of Hypertension 2015-06-01

Objective: Clinical and experimental evidence support a role for fibroblast growth factor (FGF-23) in promoting osteoclastic bone resorption, but the precise molecular mechanisms are not yet fully understood. FGF-23 has been implicated chronic kidney disease (CKD) is important humans osteogenesis. However, to date possible of secondary hyperparathyroidism (SHP) still unclear. The aim this study was investigate serum levels its potential correlation with blood pressure, atherosclerotic...

10.1097/01.hjh.0000467479.89943.a3 article EN Journal of Hypertension 2015-06-01

Hodgkin lymphoma (HL) is an uncommon malignancy that characterized by or Reed-Sternberg cells. Cardiac implications of HL remain one the least investigated subjects. There are few case reports in literature cardiac tamponade patients. We describe a 21-year-old female patient who presented with as initial presentation HL. Any pericardial effusion significant for requires immediate drainage and fluid analysis thorough investigation. Prompt identification timely intervention crucial effectively...

10.1155/2024/5597263 article EN cc-by Case Reports in Hematology 2024-01-01

Aim: To investigate the efficacy of Palmitoylethanolamide (PEA, 300 mg), Superoxide Dismutase (SOD, 70 UI), Alpha Lipoic Acid (ALA, vitamins B6 (1.5 B1 (1.1 B12 (2.5 mcg), E (7.5 nicotinamide (9 and minerals (Mg 30 mg, Zn 2.5 mg) in one tablet people with Diabetic Neuropathy (DN). Patients–methods: In present pilot study, 73 (age 63.0 ± 9.9 years, 37 women) type 2 Diabetes Mellitus (DMT2) (duration 17.5 7.3 years) DN were randomly assigned to receive either combination ten elements (2...

10.3390/nu16183045 article EN Nutrients 2024-09-10

ABSTRACT Background and Aims Tissue factor‐expressing microvesicles (MV‐TF) have been found to correlate with thrombotic complications in various diseases. Simultaneously, there is expanding research regarding the effect of coagulation cascade on liver fibrosis progression. The aim our manuscript was evaluate MV‐TF activity patients cirrhosis its correlation disease severity. Methods We prospectively enrolled 82 [11 hepatocellular cancer (Group 1), 50 2) 21 controls 3)]. Extensive workup for...

10.1111/liv.16192 article EN cc-by-nc Liver International 2024-11-27

Background and Objectives: Thyroid disease has been associated with autoimmune disorders. As systemic lupus erythematosus (SLE) is a diverse manifestations spanning across all organ systems, the relationship of SLE thyroid disorders needs investigation. In particular, attracted interest research community. The aim was to evaluate disease. Materials Methods: A cohort 45 consecutive patients, mean age 47,97 years (range 21-79 years) sex-matched controls were prospectively studied over period...

10.20944/preprints202310.0336.v1 preprint EN 2023-10-06

Previous genomic linkage studies have produced evidence linking sodium-lithium countertransport activity (Na/Li CT) with various chromosomal regions including loci harbouring glutathione S transferase (GST) genes. The aim of this study was to examine the putative association erythrocyte Na/Li CT GST T1 and M1 gene null polymorphisms.Na/Li determined in erythrocytes isolated from 85 individuals, using a standard assay procedure employing atomic absorption spectroscopy. Genotyping...

10.1515/cclm.2008.065 article EN Clinical Chemistry and Laboratory Medicine (CCLM) 2008-01-01

Objective: Some data suggest that nocturnal rather than daytime dosing of antihypertensive agents may have beneficial effects on consequent cardiovascular outcomes. This trial was designed to evaluate whether ABPM levels differ by timing drug as a possible explanation for these observations.Design and method: 103 male or female patients aged 18–80 years with “controlled” hypertension (equal less 150/90 mmHg) at least 3 months stable therapy 1 more agents, were recruited from 2 centres in...

10.1097/01.hjh.0000491431.16188.f3 article EN Journal of Hypertension 2016-08-10

D causes alterations in cell membrane lipids, probably causing abnormalities their function and especially SLC. We studied the role of SLC N H. 128 individuals (74[female] 54[male]), who were classified 4 subgroups (Subgroup A. 33-19[female] 14[male]-D+/EH+, 46,87±13,8 years old, Subgroup B. 36-23[female] 13[male] D+/EH-, 45,8±11,6 C. 31-19[female] 12[male]-D-/EH+, 45,8±15,3 D-control Group. 28-13[female] 15[male] -D-/EH-, 44,7±15,3 old. CHO, TRG, HDL measured mg/dl mmol/ltRBC/h. The was...

10.1016/s0895-7061(03)00584-3 article EN American Journal of Hypertension 2003-04-30
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