A5079980024- Antimicrobial Peptides and Activities
- CRISPR and Genetic Engineering
- Dermatology and Skin Diseases
- Pluripotent Stem Cells Research
- Nail Diseases and Treatments
- Vector-Borne Animal Diseases
- Renal and related cancers
- Biomedical Ethics and Regulation
- Wound Healing and Treatments
- Helicobacter pylori-related gastroenterology studies
- Parasitic Infections and Diagnostics
- Animal Disease Management and Epidemiology
- Animal health and immunology
- Probiotics and Fermented Foods
- Reproductive tract infections research
- Herpesvirus Infections and Treatments
- Exercise and Physiological Responses
- Clostridium difficile and Clostridium perfringens research
- Lipid Membrane Structure and Behavior
- Pharmacological Effects of Natural Compounds
- Insect and Pesticide Research
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Animal Behavior and Welfare Studies
University of Calgary
2018-2024
StemCells (United States)
2020
University of Oxford
2016-2019
Hospital for Sick Children
2019
Medical Research Council
2019
Introduction Calves are highly susceptible to gastrointestinal infection with Cryptosporidium parvum ( C. ), which can result in watery diarrhea and eventually death or impaired development. With little no effective therapeutics, understanding the host’s microbiota pathogen interaction at mucosal immune system has been critical identify test novel control strategies. Methods Herein, we used an experimental model of challenge neonatal calves describe clinical signs histological proteomic...
Abstract Cell types differentiated from induced pluripotent stem cells (iPSCs) are frequently arrested in their development program, more closely resembling a fetal rather than an adult phenotype, potentially limiting utility for downstream clinical applications. The phenotype of iPSC-derived dendritic (ipDCs) is evidenced by low expression MHC class II and costimulatory molecules, impaired secretion IL-12, poor responsiveness to conventional maturation stimuli, undermining use applications...
Digital dermatitis (DD) commonly associated with Treponema spp. infection is a prevalent infectious bovine foot disease characterized by ulcerative and necrotic lesions. Lesions DD are often classified using the M-stage scoring system, M0 indicating healthy heel skin M4 chronic Current treatments utilizing antimicrobials or chemical footbaths ineffective rarely cure Understanding function of innate immune response in pathogenesis will help to identify novel therapeutic approaches. In this...
Digital dermatitis (DD) is a skin disease in cattle characterized by painful inflammatory ulcerative lesions the feet, mostly associated with local colonization
Digital dermatitis (DD) causes lameness in cattle with substantial negative impact on sustainability and animal welfare. Although several species of Treponema bacteria have been isolated from various DD stages, their individual or synergistic roles the initiation development lesions remain largely unknown. The objective this study was to compare effects three most common (T. phagedenis, T. medium pedis), both as mixed inoculations, a murine abscess model. A total 109 5 × 108Treponema spp....
Cathelicidin peptides secreted by leukocytes and epithelial cells are microbicidal but also regulate pathogen sensing via toll-like receptors (TLRs) in the colon mechanisms that not fully understood. Herein, analyses with attaching/effacing Citrobacter rodentium model of colitis cathelicidin-deficient (Camp-/-) mice, colonic epithelia demonstrate cathelicidins prevent apoptosis sustaining post-transcriptional synthesis a TLR adapter, toll-interacting protein (TOLLIP). Cathelicidins induced...
Abstract Background Colonic goblet cells by secreting Muc2 mucin and specific proteins is critical for physically entrapping expelling invading enteropathogens. Thus, not surprising that Muc2-/- littermates exhibit increased susceptibility to attaching/effacing Citrobacter rodentium colonization. The colonic epithelium also secretes small cathelicidin peptide, which potentially interacts intimately with was presumed accumulate within the sterile inner mucus layer as a simple antimicrobial...