A5070752123- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- Immune cells in cancer
- Tea Polyphenols and Effects
- Autophagy in Disease and Therapy
- Galectins and Cancer Biology
- Invertebrate Immune Response Mechanisms
- Adenosine and Purinergic Signaling
- PARP inhibition in cancer therapy
- Glycosylation and Glycoproteins Research
- Insect Pest Control Strategies
- Chronic Lymphocytic Leukemia Research
- Toxin Mechanisms and Immunotoxins
- Neurobiology and Insect Physiology Research
- Bioactive natural compounds
- Immunotherapy and Immune Responses
- Calcium signaling and nucleotide metabolism
- Protein Tyrosine Phosphatases
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
Guangzhou University
2024
Purdue University West Lafayette
2024
Xihua University
2016-2017
Chengdu University
2016
This review highlights the recent advances in research related to role of IDO immune escape cancer and novel small-molecule inhibitors with an emphasis on their chemical structures modes action.
Toll, immune deficiency and prophenoloxidase cascade represent vital signaling pathways in insects. Peptidoglycan recognition proteins (PGRPs) are innate receptors that activate regulate the pathways. Previously, we reported BmPGPR-L4 was induced silkworm Bombyx mori larvae by bacteria peptidoglycan challenges. Here, focused on function of BmPGRP-L4 regulating expression antimicrobial peptides (AMPs). The hemolymph from BmPGRP-L4-silenced exhibited an enhanced inhibitory effect growth...
Sirt5 is a potential new drug target for the treatment of cancer, Alzheimer's disease, and Parkinson's disease. Given that norharmane an important chemical synthon some biologically compounds 9‐substituted derivatives containing negatively charged carboxyl group may accord with characteristic inhibitors, series novel were synthesized. The structures purities all characterized by 1 H NMR, 13 C MS, HPLC. By in vitro SIRT5 inhibitory assays, three ( 1a , 3a 3b ) show over 30% inhibition ratios...
Correction for ‘IDO as a drug target cancer immunotherapy: recent developments in IDO inhibitors discovery’ by Shan Qian <italic>et al.</italic>, <italic>RSC Adv.</italic>, 2016, <bold>6</bold>, 7575–7581.
<h3>Background</h3> An immunoactive complex consisting of a polyethyleneimine derivative (2E'), cytotoxic drug, and nucleotide is developed to stimulate innate immune cells in solid tumors. Each component has unique roles: 2E' induces the maturation antigen-presenting (APC) promotes release immunostimulatory cytokines. can also induce immunogenic cell death (ICD) tumor cells. Cytotoxic drugs such as paclitaxel ICD increase production cytokines APCs. Nucleotides activate various pathways both...