A5068627407- Legionella and Acanthamoeba research
- Heme Oxygenase-1 and Carbon Monoxide
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Water Treatment and Disinfection
- Phagocytosis and Immune Regulation
- Neonatal Respiratory Health Research
University of Würzburg
1998-2014
Ludwig-Maximilians-Universität München
2002
The soil amoeba Dictyostelium discoideum is a haploid eukaryote that, upon starvation, aggregates and enters developmental cycle to produce fruiting bodies. In this study, we infected single-cell stages of D. with different Legionella species. Intracellular growth in new host system was compared their the natural Acanthamoeba castellanii. Transmission electron microscopy cells revealed that legionellae reside within phagosome. Using confocal microscopy, it observed replicating,...
Legionella pneumophila is a facultative intracellular parasite able to replicate within and kill variety of eukaryotic cells. One possible killing mechanism the induction programmed cell death. Based on electron microscopy flow cytometry studies using phosphatidylserine binding protein annexin V, we could demonstrate that L. induce apoptosis in human monocytes which was clearly dependent multiplicity infection, time postinfection location bacteria. Furthermore, it became evident...
Abstract Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes ISCs exist, both α- β-ISCs regulate pH- ion-homeostasis in epithelia. Gain loss FOXI1 function are associated with human diseases, including Pendred syndrome, male infertility, renal acidosis cancers. functions were predominantly studied the context ISC specification, however, reports indicate additional early ectodermal development. Here, we re-investigated Xenopus laevis embryonic...