A5064789959- Shoulder Injury and Treatment
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Sports injuries and prevention
- Tendon Structure and Treatment
- interferon and immune responses
- Cervical and Thoracic Myelopathy
- Viral Infections and Vectors
- Inflammasome and immune disorders
- Anesthesia and Pain Management
Zhejiang University
2022-2024
First Affiliated Hospital Zhejiang University
2022-2024
The re-tear rate of rotator cuff tears (RCT) after surgical repair is high, especially in aged patients with chronic tears. Senescent tendon stem cells (s-TSCs) generally exist and chronically torn tendons are closely associated impaired tendon-to-bone healing results. present study found a positive feedback cross-talk between s-TSCs macrophages. conditioned medium (CM) from s-STCs can promote macrophage polarization mainly toward the M1 phenotype, whose CM reciprocally accelerated further...
Rheumatoid arthritis (RA) is a common autoimmune disease leading to pain, disability, and even death. Although studies have revealed that aberrant activation of STING was implicated in various diseases, the role RA remains unclear. In current study, we demonstrated pivotal pathogenesis. As accumulation dsDNA, specific stimulus for STING, feature RA, developed spherical polyethyleneimine-coated mesoporous polydopamine nanoparticles loaded with antagonist C-176 (PEI-PDA@C-176 NPs) treating RA....
Background: Unrepairable massive rotator cuff tears (UMRCTs) are challenging to surgeons owing the severely retracted musculotendinous tissues and extreme defects in tendinous tissues. Purpose: To fabricate a tendon stem cell–derived exosomes loaded scaffold (TSC-Exos-S) investigate its effects on cellular bioactivity vitro repair rabbit UMRCT model vivo. Study Design: Controlled laboratory study. Methods: TSC-Exos-S was fabricated by loading TSC-Exos type 1 collagen (COL-I) into...
Abstract Background Annulus fibrosis (AF) defects have been identified as the primary cause of disc herniation relapse and subsequent degeneration following discectomy. Stem cell-based tissue engineering offers a promising approach for structural repair. Menstrual blood-derived mesenchymal stem cells (MenSCs), type adult cell, gained attention an appealing source clinical applications due to their potential structure regeneration, with ease acquisition regardless ethical issues. Methods The...
To introduce a technique of laminotomy using common trephine to enlarge the interlaminar space at L4/5 segment for endoscopic lumbar discectomy (IELD) and report anatomical basis this procedure, technical details, as well primary clinical outcomes consecutive patient cohort with disc herniation (LDH).
Abstract Background: Annulus fibrosis (AF) defects have been identified as the primary cause of disc herniation relapse and subsequent degeneration following discectomy. Stem cell-based tissue engineering offers a promising approach for structural repair. Menstrual blood-derived mesenchymal stem cells (MenSCs), type adult cell, gained attention an appealing source clinical applications due to their potential structure regeneration, ease acquisition, low immunogenicity. Methods: The...