A5049297263- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Solid-state spectroscopy and crystallography
- Advanced MRI Techniques and Applications
- Electron Spin Resonance Studies
- Mass Spectrometry Techniques and Applications
- NMR spectroscopy and applications
- Spectroscopy and Quantum Chemical Studies
- Catalytic Processes in Materials Science
- Molecular spectroscopy and chirality
- Gas Sensing Nanomaterials and Sensors
- Quantum, superfluid, helium dynamics
Max Planck Institute for Biological Cybernetics
2021-2024
Nuclear spin hyperpolarization enables real-time observation of metabolism and intermolecular interactions in vivo. 1-13C-pyruvate is the leading hyperpolarized tracer currently under evaluation several clinical trials as a promising molecular imaging agent. Still, quest for simple, fast, efficient technique ongoing. Here, we describe that continuous, weak irradiation audio-frequency range 13C at 121 μT magnetic field (approximately twice Earth's field) order transfer from parahydrogen to...
Accurately characterizing magnetic resonance of molecules at zero to ultralow field (nTs-µTs) is challenging, due vanishingly small sensitivity, which depends on the thermal equilibrium polarization nuclear spins and instrumentation. We overcome former limitation with parahydrogen-based hyperpolarization method SABRE-SHEATH (signal amplification by reversible exchange in shield enables alignment transfer heteronuclei). This allows for continuous spin order from parahydrogen a substrate via...
Abstract Nuclear spin hyperpolarization increases the sensitivity of magnetic resonance dramatically, enabling many new applications, including real-time metabolic imaging. Parahydrogen-based signal amplification by reversible exchange (SABRE) was employed to hyperpolarize [1- 13 C]pyruvate and demonstrate C imaging in situ at 120 µT, about twice Earth’s field, with two different variants: SABRE shield enables alignment transfer heteronuclei (SABRE-SHEATH), where is transferred from...
Parahydrogen (pH
Hyperpolarized [1-13C]pyruvate is the leading metabolite used in emerging field of hyperpolarization-enhanced MRI. Signal amplification by reversible exchange (SABRE) a straight forward hyperpolarization method that has recently been shown to hyperpolarize at low (microtesla and below) magnetic fields. Here, we show commercial optical magnetometers with Rb-vapor media can be readily monitor build-up decay hyperpolarized MR signal. In addition, measure ZULF-NMR spectra various conditions,...
Abstract In recent years, parahydrogen‐induced hyperpolarization has become a focus for future medical applications. Similar to the established dynamic nuclear polarization method, biocompatible bolus from hyperpolarized sample can be produced in vivo studies. However, this requires removing toxic hydrogenation catalysts, which inevitably must used. Additionally, ratio between substrate (e. g. pyruvate) and mandatory catalyst also maintained. Even smallest differences lead reduction...
This study pioneers the two-field correlation spectroscopy (COSY) in zero to ultralow field (ZULF) liquid state NMR, employing hyperpolarized [1-$^{13}$C]pyruvate as a model system. We demonstrate successful integration of signal amplification by reversible exchange (SABRE) for hyperpolarization, enabling detection ZULF COSY spectra with increased sensitivity. The use cycling allows acquisition at varying magnetic strengths, including zero-field conditions. enables insight into both...
The Cover Feature illustrates the quest for efficient Signal Amplification By Reversible Exchange (SABRE). It shows conventional SABRE on left side and method alt-SABRE right side, where polarization evolution switches back forth between strong coupling regime at ∼1 mT weak ∼50 mT. With this effect of 15N can be boosted by least 30%. authors thank DEAL project promoting open access to research publications. More information found in Communication Andrey N. Pravdivtsev, Kai Buckenmaier co-workers.
We used signal amplification by reversible exchange of parahydrogen (SABRE) at low (~1 mT) and ultra-low μT, ULF) magnetic fields. proposed ULF correlation spectroscopy (COSY) method to analyze PHIP spin order in real-time. Coherences up the third-order were observed experimentally. Furthermore, we analyzed SABRE alternating fields (alt-SABRE). measured evolution 1 H- 15 N zero-quantum coherences have shown that they persist during field alternation depend on strength. The resulting...
Parahydrogen (pH2) is a convenient and cost efficient source for magnetic resonance signal enhancement. Transient interaction of pH2 with metal organic complex in amplification by reversible exchange (SABRE) experiment enabled more than 10% polarization some 15N molecules. Here, we analyzed variant SABRE, consisting an outer field alternating between low ~1 \muT, where transfer takes place, higher >50 \muT (alt-SABRE). We found effects both these fields on amplitude the frequency transfer....