A5018383392- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Solid-state spectroscopy and crystallography
- Electron Spin Resonance Studies
- Cold Atom Physics and Bose-Einstein Condensates
- NMR spectroscopy and applications
- Medical Imaging Techniques and Applications
- Physics of Superconductivity and Magnetism
- Quantum, superfluid, helium dynamics
- Nonlinear Dynamics and Pattern Formation
- Molecular spectroscopy and chirality
- Superconducting Materials and Applications
- Magnetism in coordination complexes
- Spectroscopy and Quantum Chemical Studies
- Functional Brain Connectivity Studies
- Silicon and Solar Cell Technologies
- Lanthanide and Transition Metal Complexes
- 3D IC and TSV technologies
- Particle accelerators and beam dynamics
- Electrostatic Discharge in Electronics
- Quantum and electron transport phenomena
- Lower Extremity Biomechanics and Pathologies
- Foot and Ankle Surgery
- Advanced Electron Microscopy Techniques and Applications
Max Planck Institute for Biological Cybernetics
2016-2025
University Medical Center
2024
Kiel University
2024
Max Planck Society
2014-2021
Novosibirsk Institute of Organic Chemistry
2021
Center for Excellence in Brain Science and Intelligence Technology
2021
Novosibirsk State University
2021
University of California, Berkeley
2013-2018
Lawrence Berkeley National Laboratory
2013
University of Tübingen
2007-2012
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTInstrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization TechniquesAndreas B. Schmidt*Andreas SchmidtDepartment of Radiology−Medical Physics, Medical Center, Faculty Medicine, University Freiburg, Killianstraße 5a, Freiburg 79106, GermanyGerman Cancer Consortium (DKTK), partner site and German Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany*Email: [email protected]More by Andreas SchmidtView...
Nuclear spin hyperpolarization enables real-time observation of metabolism and intermolecular interactions in vivo. 1-13C-pyruvate is the leading hyperpolarized tracer currently under evaluation several clinical trials as a promising molecular imaging agent. Still, quest for simple, fast, efficient technique ongoing. Here, we describe that continuous, weak irradiation audio-frequency range 13C at 121 μT magnetic field (approximately twice Earth's field) order transfer from parahydrogen to...
We present in vivo images of the human brain acquired with an ultralow field MRI (ULFMRI) system operating at a magnetic B0 ~ 130 μT. The features prepolarization proton spins Bp 80 mT and detection NMR signals superconducting, second-derivative gradiometer inductively coupled to superconducting quantum interference device (SQUID). report measurements longitudinal relaxation time T1 tissue, blood, scalp fat Bp, cerebrospinal fluid B0. use these values construct inversion recovery sequences...
A multinuclei imaging setup with the capability to acquire both sodium ((23) Na) and proton ((1) H) signals at 9.4 Tesla is presented. The main objective was optimize coil performance (23) Na frequency while still having ability satisfactory (1) H images.The consisted of a combination three radio (RF) coils arranged in layers: innermost layer 27-channel receive helmet which surrounded by four-channel transceiver array. outer dipole array for B0 shimming anatomical localization. Transmit...
Abstract Die Magnetresonanz (MR) von Kernspins ist einer der nützlichsten physikalischen Effekte für die humane Bildgebung, ebenso wie Aufklärung molekularen Strukturen und chemische Analyse. Das volle Potential MR kann jedoch kaum genutzt werden, da nur ein geringer Bruchteil aller polarisiert, sprich in einem äußeren magnetischen Feld ausgerichtet werden. Hyperpolarisierungsmethoden versuchen, Polarisierung damit das MR‐Signal auf anderem Wege zu erhöhen. Eine einzigartige Quelle reiner...
In cancer diagnostics, magnetic resonance imaging (MRI) uses contrast agents to enhance the distinction between target tissue and background. Several promising approaches have been developed increase MRI sensitivity, one of which is Overhauser dynamic nuclear polarization (ODNP)-enhanced (OMRI). this study, a macromolecular construct based on human serum albumin nitroxyl radicals (HSA-NIT) was using new synthesis method that significantly increased modification 21 nitroxide residues per...
Accurately characterizing magnetic resonance of molecules at zero to ultralow field (nTs-µTs) is challenging, due vanishingly small sensitivity, which depends on the thermal equilibrium polarization nuclear spins and instrumentation. We overcome former limitation with parahydrogen-based hyperpolarization method SABRE-SHEATH (signal amplification by reversible exchange in shield enables alignment transfer heteronuclei). This allows for continuous spin order from parahydrogen a substrate via...
Nuclear magnetism underpins areas such as medicine in magnetic resonance imaging (MRI). Hyperpolarization of nuclei enhances the quantity and quality information that can be determined from these techniques by increasing their signal to noise ratios orders magnitude. However, some hyperpolarization rely on use low ultralow fields (ULF) (nTs-mTs). The broadband character ultrasensitive field sensitivity superconducting quantum interference devices (SQUID) allow for probing nuclear at fields,...
Abstract Objective Low-field magnetic resonance imaging is currently developing into a valuable diagnostic tool due to its simplicity of magnet array designs. Particularly, this allows the development scanners as part educational workshops, thus ensuring knowledge transfer and empowering local scientists design tailored solutions for specific problems. To obtain maximum performance, needs be shimmed requiring an automated system measuring spatial field distribution. Methods A self-designed...
Abstract Nuclear spin hyperpolarization increases the sensitivity of magnetic resonance dramatically, enabling many new applications, including real-time metabolic imaging. Parahydrogen-based signal amplification by reversible exchange (SABRE) was employed to hyperpolarize [1- 13 C]pyruvate and demonstrate C imaging in situ at 120 µT, about twice Earth’s field, with two different variants: SABRE shield enables alignment transfer heteronuclei (SABRE-SHEATH), where is transferred from...
The goal of cartilage repair techniques such as microfracture (MFX) or matrix-associated autologous chondrocyte transplantation (MACT) is to produce tissue (RT) with sufficient glycosaminoglycan (GAG) content. Sodium magnetic resonance imaging (MRI) offers a direct and noninvasive evaluation the GAG content in native RT. In femoral cartilage, this method was able distinguish between RTs produced by MFX MACT having different contents. However, it needs be clarified whether sodium MRI can...
Ultra-low-field (ULF) nuclear magnetic resonance (NMR) is a promising spectroscopy method allowing for, e.g., the simultaneous detection of multiple nuclei. To overcome low signal-to-noise ratio that usually hampers wider application, we present here an alternative approach to ULF NMR, which makes use hyperpolarizing technique signal amplification by reversible exchange (SABRE). In contrast standard parahydrogen hyperpolarization, SABRE can continuously hyperpolarize 1 H as well other...
Parahydrogen (pH
Hyperpolarized [1-13C]pyruvate is the leading metabolite used in emerging field of hyperpolarization-enhanced MRI. Signal amplification by reversible exchange (SABRE) a straight forward hyperpolarization method that has recently been shown to hyperpolarize at low (microtesla and below) magnetic fields. Here, we show commercial optical magnetometers with Rb-vapor media can be readily monitor build-up decay hyperpolarized MR signal. In addition, measure ZULF-NMR spectra various conditions,...
Fractional Josephson vortices carry a magnetic flux Phi, which is fraction of the quantum Phi_0 ~ 2.07x10^{-15} Wb. Their properties are very different from usual integer fluxons. In particular, fractional pinned and have an oscillation eigenfrequency expected to be within plasma gap. Using microwave spectroscopy, we investigate dependence vortex on its $\Phi$ bias current. The experimental results in good agreement with theoretical predictions.
Ultralow-field (ULF) nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) are promising methods allowing for, e.g., the simultaneous detection of multiple nuclei or in vicinity metals. To overcome inherently low signal-to-noise ratio that usually hampers a wider application, we present an alternative approach to prepolarized ULF MRS employing hyperpolarization techniques like signal amplification by reversible exchange (SABRE) Overhauser dynamic polarization (ODNP). Both allow...
The development of hyperpolarization technologies enabled several yet exotic NMR applications at low and ultra-low fields (ULF), where without even the detection a signal from analytes is challenge. Herein, we present method for simultaneous excitation observation homo- heteronuclear multiple quantum coherences (from zero up to third-order), which give an additional degree freedom ULF experiments, chemical shift variation negligible. approach based on correlated spectroscopy (COSY); its...
Nuclear magnetism underpins areas such as medicine in magnetic resonance imaging (MRI). Hyperpolarization of nuclei enhances the quantity and quality information that can be determined from these techniques by increasing their signal to noise ratios orders magnitude. However, some hyperpolarization rely on use low ultralow fields (ULF) (nTs-mTs). The broadband character ultrasensitive field sensitivity superconducting quantum interference devices (SQUID) allow for probing nuclear at fields,...
Efficient acquisition of triple-quantum-filtered (TQF) sodium images at ultra-high field (UHF) strength.A three-pulse preparation and a stack double-spirals were used for the TQF 9.4 Tesla. The flip angles TQ smoothly reduced toward edge k-space along partition-encoding direction. In doing so, specific absorption rate could be while preserving maximal signal intensity partitions most relevant image contrast in center k-space. Simulations, phantom vivo measurements to demonstrate usefulness...
The efficacy in 1H Overhauser dynamic nuclear polarization liquids at ultralow magnetic field (ULF, B0 = 92 ± 0.8 µT) and (Bp 1-10 mT) was studied for a broad variety of 26 different spin probes. Among others, piperidine, pyrrolidine, pyrroline radicals specifically synthesized this study, along with some well-established commercially available nitroxides, were investigated. Isotope-substituted variants, sterically shielded reduction-resistant biradicals included the measurements. maximal...
We consider a fractional Josephson vortex in long $0\text{\ensuremath{-}}\ensuremath{\kappa}$ junction. A uniformly applied bias current exerts Lorentz force on the vortex. If exceeds critical current, an integer fluxon is torn off $\ensuremath{\kappa}$ and junction switches to voltage state. In presence of thermal fluctuations escape process takes place with finite probability already at subcritical values current. experimentally investigate thermally induced by high-resolution measurements...
In long Josephson junctions with multiple discontinuities of the phase, fractional vortex molecules are spontaneously formed. At each discontinuity point a carrying magnetic flux $|\Phi|<\Phi_0$, $\Phi_0\approx 2.07\times 10^{-15}$ Wb being quantum, is pinned. Each has an oscillatory eigenmode frequency that depends on $\Phi/\Phi_0$ and lies inside plasma gap. We experimentally investigate dependence eigenfrequencies two-vortex molecule distance between vortices, their topological charge...