A5085887048- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Advanced NMR Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Solid-state spectroscopy and crystallography
- Functional Brain Connectivity Studies
- Cardiac pacing and defibrillation studies
- Membrane-based Ion Separation Techniques
- Potassium and Related Disorders
- Non-Invasive Vital Sign Monitoring
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Spectroscopy Techniques in Biomedical and Chemical Research
Max Planck Institute for Biological Cybernetics
2015-2023
Max Planck Society
2018-2019
Ludwig-Maximilians-Universität München
2013
Center for Integrated Protein Science Munich
2013
Max Planck Institute of Psychiatry
2013
University of Manchester
2013
University of the Witwatersrand
1972
Background— Sinus node dysfunction (SND) is a major clinically relevant disease that associated with sudden cardiac death and requires surgical implantation of electric pacemaker devices. Frequently, SND occurs in heart failure hypertension, conditions lead to instability the heart. Although pathologies acquired have been studied extensively, little known about molecular cellular mechanisms cause congenital SND. Methods Results— Here, we show HCN1 protein highly expressed sinoatrial...
Ultralow-field (ULF) nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) are promising methods allowing for, e.g., the simultaneous detection of multiple nuclei or in vicinity metals. To overcome inherently low signal-to-noise ratio that usually hampers a wider application, we present an alternative approach to prepolarized ULF MRS employing hyperpolarization techniques like signal amplification by reversible exchange (SABRE) Overhauser dynamic polarization (ODNP). Both allow...
Motivation: BOLD fMRI is widely used as an indirect measure of neuronal activity. However, the spatial and temporal specificity signal still under debate. Goal(s): Being able to both hemodynamics activity simultaneously with can help improve interpretation signal. Approach: A combined in-bore setup for concurrent intrinsic optical imaging, calcium imaging ultra-high field in rats was designed. Results: Measurements BOLD, hemodynamic signals high resolution reveal correlation between these...
Intrinsic optical imaging (IOI) is a well established technique to quantify activation‐related hemodynamical changes at the surface of brain, which can be used investigate underlying processes BOLD signal formation. To directly and quantitatively relate IOI fMRI, simultaneous measurements with two modalities are necessary. Here, novel technical solution for completely in‐bore setup presented, uses only magnetic field proof components thus allows concurrent recordings quality similar that...