A5077847249- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Bacteriophages and microbial interactions
- Pancreatic and Hepatic Oncology Research
- Pharmacological Effects and Toxicity Studies
- Eosinophilic Esophagitis
- Plant Virus Research Studies
- Virology and Viral Diseases
- Immune Cell Function and Interaction
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Nonmelanoma Skin Cancer Studies
- Glioma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- Free Radicals and Antioxidants
- Food Allergy and Anaphylaxis Research
- Adenosine and Purinergic Signaling
- Breast Cancer Treatment Studies
- Cutaneous Melanoma Detection and Management
- Reconstructive Surgery and Microvascular Techniques
- Allergic Rhinitis and Sensitization
University of Toledo
2023-2024
University of Toledo Medical Center
2023
The Ohio State University
2020
Abstract Introduction Melanoma, a deadly form of skin cancer, has witnessed notable increase in incidence over the past decades. Despite advancements treatment, it remains significant cause cancer mortality. Understanding demographic trends and variations melanoma mortality is crucial for addressing disparities implementing effective interventions. Methods Using Centers Disease Control Wide Ranging Online Data Epidemiologic Research (CDC WONDER) database, we analyzed data United States from...
Genomic studies have indicated that certain bacterial lineages such as the Bacteroidetes lack Shine-Dalgarno (SD) sequences, and yet with few exceptions ribosomes of these organisms carry canonical anti-SD (ASD) sequence. Here, we show purified from Flavobacterium johnsoniae, a representative Bacteroidetes, fail to recognize SD sequence mRNA in vitro. A cryo-electron microscopy structure complete 70S ribosome F. johnsoniae at 2.8 Å resolution reveals ASD is sequestered by ribosomal proteins...
Recent advances in targeted therapy using monoclonal antibodies have revolutionized care many fields, and dupilumab for the treatment of moderate-severe atopic dermatitis is no exception. While on a trial loading dose dupilumab, 25-year-old white male with past medical history significant anaphylaxis after ingesting peanuts tree nuts did not experience accidentally consuming almonds. Similarly to anti-IgE, large-scale inhibition IL-4 IL-13 signaling various immune cells involved type II...
e24108 Background: Metabolic encephalopathy is a serious but reversible condition that characterized by diffuse impairment of cognitive function due to the overabundance various metabolites or toxins. Hyperammonemia ( > 80 μg/dL 47 μmol/L) well-known cause metabolic and also rare side effect 5-Fluorouracil (5-FU) chemotherapy. Constipation renal failure are two known risk factors for developing hyperammonemic with 5-FU use. Capecitabine prodrug commonly used as more tolerated convenient...
Abstract Introduction Pancreatic cancer is a significant public health concern and leading cause of cancer-related deaths worldwide. This study aimed to investigate pancreatic mortality trends disparities in the United States (US) from 1999 2020. Methods Data were obtained Centers for Disease Control (CDC) Wide-Ranging Online Epidemiologic Research database. Mortality rates age-adjusted standardized year 2000 US population. Joinpoint regression was used analyze temporal (AAMRs) by...
The phospho- (P) protein, the co-factor of RNA polymerase large (L) vesicular stomatitis virus (VSV, a prototype nonsegmented negative-strand viruses) plays pivotal roles in transcription and replication. However, precise mechanism underlying transcriptional transactivation by P protein has remained elusive. Here, using an vitro system series deletion mutants we mapped region encompassing residues 51-104 as domain (TAD) that is critical for terminal de novo initiation, initial step synthesis...