A5069193732- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic Cross-Coupling Reactions
- biodegradable polymer synthesis and properties
- Polymer crystallization and properties
- Chemical synthesis and alkaloids
- Axial and Atropisomeric Chirality Synthesis
- Polymer Nanocomposites and Properties
- Advanced Cellulose Research Studies
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Alkaloids: synthesis and pharmacology
- Synthesis and Catalytic Reactions
- Thermochemical Biomass Conversion Processes
- Asymmetric Synthesis and Catalysis
- Biofuel production and bioconversion
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
- Molecular spectroscopy and chirality
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Synthetic Organic Chemistry Methods
- Organoboron and organosilicon chemistry
- Fiber-reinforced polymer composites
- Microbial Natural Products and Biosynthesis
Huaibei Normal University
2023-2024
The University of Texas at San Antonio
2021-2024
University of Central Florida
2020
Tsinghua University
2017-2019
Florida State University
2019
University of Science and Technology of China
2011-2018
Hefei National Center for Physical Sciences at Nanoscale
2018
Hefei University
2016
A Pd/norbornene/Cu cooperative catalysis for the efficient synthesis of 2-(arylthio)aryl ketones from aryl halides and thioesters has been developed. The first example by palladium, norbornene, copper, wherein C(O)–S bond is cleaved a PdII palladacycle with assistance CuI, observed.
A Pd-catalyzed chemoselective Catellani reaction of iodopyrroles was developed. The rare chemoselectivity between two different aryl halides realized by optimizing the kinetics steps this multicomponent process. new developed method led to rapid synthesis rhazinal in a highly efficient manner.
Three-component cross-coupling cocatalyzed by palladium and norbornene is reported for the synthesis of biaryl atropisomers. This domino reaction gave optimal yield enantioselectivity with a P,C-type ligand bearing axial chirality P chiral center. The process showed advantages over traditional because its step economy compatibility readily available ortho-substituted aryl halides, which could, therefore, be used instead continuously trisubstituted halides.
Progress in the development of photocatalytic reactions requires a detailed understanding mechanisms underpinning observed reactivity, yet mechanistic details many systems, especially those that involve electron donor–acceptor complexes, have remained elusive. We report herein and combined computational study alkene 1,2-diacylation enables regioselective installation two different acyl groups, establishing direct, tricomponent access to 1,4-diketones, key intermediates heterocyclic medicinal...
Sulfonamides are prominently featured in organic synthesis and medicinal chemistry. Yet, a general synthetic platform for the modular construction of aryl sulfonamides remains elusive. Herein, metal-free photoredox-catalyzed three-component via an sulfonyl ammonium salt intermediate, which was generated situ SET event, has been established. A variety structurally diverse primary, secondary, tertiary were synthesized rapidly from abundant amines or sodium azide under mild conditions. Notably,...
Diverse amines and amino acids are now readily accessed from carboxylic acids, aldehydes, amine precursors in a direct decarboxylative reaction enabled by homogeneous triple catalytic system based on acridine photocatalysis.
A catalytically asymmetric palladium/norbornene-catalyzed reaction is reported, where α-aryl tetrahydroquinoline derived phosphoramidite L15 found to be the optimum ligand. Taking advantage of this transformation, concise and unified enantioselective syntheses (+)-rhazinal, (+)-rhazinilam, (+)-kopsiyunnanine C1, C2, C3 are realized.
This review gave a brief account for the palladium-catalyzed chemoselective Catellani <i>ortho</i>-arylation reactions. Two possible methods were discussed which usually used to control chemoselectivities of these Additionally, examples reaction in natural product synthesis are also reviewed.
We reported the introduction of a functionalized methyl group into <italic>ortho</italic>-position using Catellani reaction.
Amines are centrally important motifs in medicinal chemistry and biochemistry, indispensable intermediates linchpins organic synthesis. Despite their cross-disciplinary prominence, synthetic access to amine continues rely on two-electron approaches based reductions additions of organometallic reagents, limiting accessible chemical space necessitating stepwise preassembly precursors. We report herein a homogeneous photocatalytic tricomponent decarboxylative radical-mediated construction that...
This work describes a method for the difunctionalization of aryl iodides to generate polysubstituted arenes via Pd catalysis. The reaction hinges on unique interplay between norbornene and metal catalyst impart guided ortho C-H alkylation event followed by programmatic ipso borylation provide diverse array substituted arene products. utility this transformation is demonstrated through functionalization boronic ester variety valuable functionalities.
An efficient photoredox-catalyzed three-component coupling reaction of aryl amine, glyoxalate and alkyltrifluoroborates has been reported.
Aryl sulfonyl fluorides are prominently featured in organic synthesis and medicinal chemistry. Herein, a metal-free photoredox-catalyzed three-component assembly of aryl fluoride via ammonium salt intermediate has been reported. A variety structurally diverse were synthesized rapidly from dibenzothiophenium (DBT) salts under mild conditions by using KHF2 as the fluorine source. Notably, this methodology can be employed an efficient sustainable approach for late-stage drug...
Abstract Review: 58 refs.
Abstract A Pd‐catalyzed chemoselective Catellani reaction of iodopyrrole (I) is developed.