A5074954984- Cancer Research and Treatments
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
East China Normal University
2022-2023
Shanghai Changning Maternity and Infant Health Hospital
2022
Abstract Immunotherapy has become established as major treatment modality for multiple types of solid tumors, including colorectal cancer. Identifying novel immunotherapeutic targets to enhance anti-tumor immunity and sensitize current immune checkpoint blockade (ICB) in cancer is needed. Here we report the histone demethylase PHD finger protein 8 (PHF8, KDM7B), a Jumonji C domain-containing that erases repressive methyl marks, an essential mediator escape. Ablation function PHF8 abrogates...
Genotoxic agents remain the mainstay of cancer treatment. Unfortunately, clinical benefits are often countered by a rapid tumor adaptive response. Here, we report that oncoprotein B cell lymphoma 6 (BCL6) is core component confers solid resistance to genotoxic stress. Multiple promoted BCL6 transactivation, which was positively correlated with weakened therapeutic efficacy and worse outcome. Mechanistically, discovered treatment agent etoposide led transcriptional reprogramming multiple...