A5092236605- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Antibiotic Resistance in Bacteria
- Bacterial Genetics and Biotechnology
- Invertebrate Immune Response Mechanisms
- Venomous Animal Envenomation and Studies
- Aquaculture disease management and microbiota
- CRISPR and Genetic Engineering
- vaccines and immunoinformatics approaches
- Bacterial biofilms and quorum sensing
Universitat Autònoma de Barcelona
2023-2024
Barcelona Biomedical Research Park
2023
Universitat Pompeu Fabra
2023
Antimicrobial peptides (AMPs) are molecules found in most organisms, playing a vital role innate immune defense against pathogens. Their mechanism of action involves the disruption bacterial cell membranes, causing leakage cellular contents and ultimately leading to death. While AMPs typically lack defined structure solution, they often assume conformation when interacting with membranes. Given this structural flexibility, we investigated whether intrinsically disordered regions (IDRs)...
The alarming rise of antibiotic-resistant bacterial infections is driving efforts to develop alternatives conventional antibiotics. In this context, antimicrobial peptides (AMPs) have emerged as promising candidates for their ability target a broad range microorganisms. However, the development AMPs with optimal potency, selectivity, and/or stability profiles remains challenge. To address it, computational tools predicting AMP properties and designing novel gained increasing attention....
β-defensins are one of the most abundant and studied families antimicrobial peptides (AMPs). Because their selective toxicity to bacterial membranes a broad spectrum microbicidal action, regarded as potential therapeutic agents. This work focuses on β-defensin-like AMP from spiny lobster Panulirus argus (hereafter referred panusin or PaD). is structurally related mammalian defensins via presence an αβ domain stabilized by disulfide bonds. Previous studies PaD suggest that its C-terminus...
Abstract Efflux is one of the mechanisms employed by Gram-negative bacteria to become resistant routinely used antibiotics. The inhibition efflux targeting their regulators a promising strategy re-sensitise bacterial pathogens AcrAB-TolC main Resistance-Nodulation-Division pump in Enterobacteriaceae. MarA an AraC/XylS family global regulator that regulates more than 40 genes related antimicrobial resistance phenotype, including acrAB . aim this work was understand role N-terminal helix...
Antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics in the face of ever-increasing resistance. Our research has focused on crotalicidin (Ctn), an AMP from snake venom, and fragment thereof, Ctn[15-34], with improved vitro antimicrobial anticancer activities remarkable serum stability. As retroenantio versions both AMPs maintained favorable profiles, this work we evaluate vivo efficacy na-tive-sequence their counterparts murine infection model...
Antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics in the face of ever-increasing resistance. However, many AMPs fail progress into clinics due unexpected difficulties found preclinical vivo phases. Our research has focused on crotalicidin (Ctn), an AMP from snake venom, and fragment thereof, Ctn[15-34], with improved vitro antimicrobial anticancer activities remarkable serum stability. As retroenantio versions both maintained favorable profiles,...
Efflux is one of the mechanisms employed by Gram-negative bacteria to become resistant routinely used antibiotics. The inhibition efflux targeting their regulators a promising strategy re-sensitize bacterial pathogens AcrAB-TolC main resistance-nodulation-division pump in Enterobacteriaceae. MarA an AraC/XylS family global regulator that regulates more than 40 genes related antimicrobial resistance phenotype, including acrAB. aim this work was understand role N-terminal helix mechanism DNA...