A5021237984- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Erythrocyte Function and Pathophysiology
- Genetic Associations and Epidemiology
- Cellular transport and secretion
- Neurotransmitter Receptor Influence on Behavior
- Adenosine and Purinergic Signaling
Stanley Medical Research Institute
2013-2024
Whole-genome expression profiling in postmortem brain tissue has recently provided insight into the pathophysiology of schizophrenia. Previous microarray and RNA-Seq studies identified several biological processes including synaptic function, mitochondrial function immune/inflammation response as altered cortex subjects with Now using data from hippocampus, we have 144 differentially expressed genes schizophrenia cases compared unaffected controls. Immune/inflammation was main process...
Glutamic acid decarboxylase 67 (GAD67) is a gamma-aminobutyric (GABA) synthesis enzyme associated with the function of other neurotransmitter receptors, such as N-methyl-D-aspartate (NMDA) receptor and cannabinoid 1. However, role GAD67 in development different abused drug-induced reward behaviors remains unknown. In order to elucidate mechanisms substance use disorder, it crucial study changes biomarkers within brain's circuit induced by drug use.