A5043907790- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Bioactive Compounds and Antitumor Agents
- Neurobiology and Insect Physiology Research
- Synthesis of Indole Derivatives
- Toxin Mechanisms and Immunotoxins
- Immune Cell Function and Interaction
Institute of Advanced Chemistry of Catalonia
2021-2024
Consejo Superior de Investigaciones Científicas
2021-2024
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
1. Abstract The metabotropic glutamate receptor 5 (mGlu ) is widely expressed in the brain, where it plays an important role synaptic plasticity, learning and memory, making a therapeutic target of interest various neurological disorders. In this study, we developed photoswitchable positive allosteric modulator (PAM) mGlu , as novel tool for clinically relevant drug target. To that aim, used azologisation strategy PAM agonist VU0424465 leading to molecule azoglurax. We observed reversible...
Natural Killer T (NKT) cells play an important role in the immune response and can be activated by glycolipids presented CD1d protein. We present MCS-0208, unprecedented arylthioether-phytoceramide able to induce potent invariant NKT (iNKT) cell activation, notably when tested human iNKT cells. This arylsphingolipid analog has a simple phenyl group containing single hydroxyl substituent as surrogate of sugar ring. The phenylthioether structure contrasts with α-galactosylceramide (1),...
Background and Purpose Metabotropic Glutamate Receptors (mGlu) regulate multiple functions in the nervous systems are involved disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an unmet need. Photopharmacology can address this concern by means of photoswitchable compounds such as Optogluram, which a positive allosteric modulator (PAM) mGlu4 that enables to optically control physiological responses high precision. Optogluram not fully...