A5016679278- Neuroendocrine Tumor Research Advances
- Myasthenia Gravis and Thymoma
- Lung Cancer Research Studies
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
University of Göttingen
2022
Universitätsmedizin Göttingen
2017-2019
IntroductionThe WHO classification of pulmonary neuroendocrine tumors (PNETs) is also used to classify thymic NETs (TNETs) into typical and atypical carcinoid (TC AC), large cell carcinoma (LCNEC), small (SCC), but little known about the usability alternative systems.MethodsOne hundred seven TNET (22 TC, 51 AC, 28 LCNEC, 6 SCC) from 103 patients were classified according WHO, European Neuroendocrine Tumor Society, a grading-related PNET classification. Low coverage whole-genome sequencing...
Tumor grading is a robust prognostic predictor in patients with neuroendocrine neoplasms (NEN) and guides therapy, especially tumors high proliferation. NEN can be separated into well-differentiated poorly differentiated types. The more aggressive have been further (NET G3) better prognosis carcinomas (NEC) worse prognosis. Despite this distinction’s tremendous clinical therapeutic relevance, optimal diagnostic biomarkers are still lacking. In study, we analyzed the protein expression impact...