A5011557273- Multiple Myeloma Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Signaling Pathways in Disease
- Acute Myeloid Leukemia Research
- HIV Research and Treatment
- Metabolism, Diabetes, and Cancer
- Kruppel-like factors research
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Hematological disorders and diagnostics
- Pancreatic function and diabetes
- Phytochemical compounds biological activities
- Drug Transport and Resistance Mechanisms
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- Genetics and Neurodevelopmental Disorders
- Hemoglobinopathies and Related Disorders
- Synthesis and Biological Evaluation
- Lung Cancer Treatments and Mutations
Columbia University Irving Medical Center
2023-2025
Amyloidosis Foundation
2024-2025
Columbia University
2024-2025
Herbert Irving Comprehensive Cancer Center
2024-2025
Icahn School of Medicine at Mount Sinai
2022-2024
Tisch Cancer Institute
2024
Mount Sinai Hospital
2023
Princeton University
2018-2019
Significance To shed light on the host range of Zika virus (ZIKV), we surveyed virus’ ability to infect cells evolutionarily diverse species. ZIKV replicates efficiently in human, great ape, Old and New World monkey, but not rodent cells. These observations correlated with ZIKV’s blunt cGAS/STING signaling pathway all primate tested mice. We demonstrate that an enzyme shared by many flaviviruses (NS2B3) is responsible for functionally inactivating this antiviral defense. Our results...
Abstract The objective of our study was to report real-world data on the safety and efficacy standard-of-care teclistamab in patients with relapsed/refractory multiple myeloma (MM). This is a multi-institutional retrospective cohort included all consecutive that received at least one dose up until August 2023. One hundred ten were included, whom, 86% had triple-class refractory disease, 76% penta-refractory 35% prior exposure B-cell maturation antigen (BCMA)-targeting therapies. overall...
Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental challenge for type 1 and 2 diabetes. Recently, small molecule inhibitors the kinase DYRK1A have proven effective in inducing adult human proliferate, but their detailed mechanism action incompletely understood. We interrogated our insulinoma cell transcriptomic databases seeking understand why insulinomas while normal do not. This search reveals DREAM complex as central regulator quiescence cells. The...
ABSTRACT Myeloma cast nephropathy (MCN) is a driver of renal failure in newly diagnosed multiple myeloma (NDMM) and has been historically associated with increased early mortality. Since patients moderate to severe insufficiency are typically excluded from trials, we performed retrospective study characterize modern‐era outcomes MCN. We reviewed 274 consecutive NDMM 2017 2023 at an academic center identified 46 (16.8%) Among them, 96% had received bortezomib 67% anti‐CD38 + monoclonal...
Differences in immune responses across species can contribute to the varying permissivity of same viral pathogen. Understanding how our closest evolutionary relatives, nonhuman primates (NHPs), confront pathogens and these have evolved over time could shed light on host range barriers, especially for zoonotic infections. Here, we analyzed cell-intrinsic immunity primary cells from broadest panel NHP interrogated date, including humans, great apes, Old New World monkeys. Our analysis their...
The Glasgow prognostic score (GPS) and CAR-HEMATOTOX (CAR-HT) identify multiple myeloma (MM) patients at high risk for immune-mediated toxicity early mortality with cellular immunotherapy. However, their association outcomes in receiving T-cell redirecting bispecific antibodies (bsAb) is unclear. This multi-centre retrospective study examines the of baseline GPS CAR-HT scores 126 MM treated bsAb. Overall, 19% were identified as but did not experience increased or mortality. Conversely,...
The restricted host tropism of hepatitis C virus (HCV) remains incompletely understood, especially post-entry, and has hindered developing an immunocompetent, small animal model. HCV replication in non-permissive species may be limited by incompatibilities between the viral machinery orthologs essential factors, like cyclophilin A (CypA). We thus compared ability CypA from mouse, tree shrew, seven non-human primate to support replication, finding that murine only partially rescued...
7555 Background: Myeloma cast nephropathy (MCN) has been a well-known negative predictive marker in newly diagnosed multiple myeloma (NDMM). Anti-CD38 + monoclonal antibodies (mAb) have improved outcomes, but little is known about their impact patients with MCN. We performed retrospective cohort study to investigate the outcomes of MCN era anti-CD38 mAb-based frontline therapy. Methods: 115 NDDM received mAb from 11/15/18 1/24/23. was defined as evidence light chain casts on biopsy, serum...